Table 6 Univariate and multivariate analyses of prognostic factors in GEICAM/9906
From: PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers
MVA analysis for OS | Univariate analysis | Multivariate analysis (backward/forward stepwise selection) | ||||||
|---|---|---|---|---|---|---|---|---|
Signatures | HR | Lower 95% | Upper 95% | p-value | HR | Lower 95% | Upper 95% | p-value |
ARM FEC-P vs. FEC | 0.708 | 0.528 | 0.948 | 0.021 | 0.734 | 0.543 | 0.993 | 0.045 |
Grade 3 vs. 1-2 | 1.745 | 1.297 | 2.346 | <0.001 | 1.335 | 0.962 | 1.853 | 0.084 |
Nodes >3 vs. 1-3 | 2.103 | 1.574 | 2.808 | <0.001 | 1.882 | 1.391 | 2.546 | 0.000 |
Tumor size >2 cm vs. ≤2cm | 2.089 | 1.510 | 2.890 | <0.001 | 1.724 | 1.224 | 2.427 | 0.002 |
Age >50 vs ≤50 | 1.189 | 0.890 | 1.589 | 0.242 | 1.012 | 0.999 | 1.026 | 0.078 |
ER status by IHC + vs. - | 0.619 | 0.449 | 0.855 | 0.004 | - | - | - | - |
ER status by GE + vs. - | 0.536 | 0.387 | 0.741 | <0.001 | 0.630 | 0.438 | 0.906 | 0.013 |
Clinical HER2 status + vs. - | 1.389 | 0.9532 | 2.024 | 0.0872 | - | - | - | - |