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Table 3 Current practice in communication of reclassified variants from laboratory to clinician

From: Reinterpretation, reclassification, and its downstream effects: challenges for clinical laboratory geneticists

 

Reclassificatsion

B (1)

LB (2)

VUS (3)

LP (4)

P (5)

Initial classification

B (1)

 

NO

Varies

YES

YES

LB (2)

NO

 

Varies

YES

YES

VUS (3)

Varies

Varies

 

YES

YES

LP (4)

YES

YES

YES

 

YES

P (5)

YES

YES

YES

Varies

 
  1. Variants are shown with their initial classification and after reclassification, ranging from class 1 to class 5 (representing benign, likely benign, variant of uncertain significance, likely pathogenic, and pathogenic)
  2. Yes - This type of reclassification is communicated from laboratory to clinician
  3. No - This type of reclassification is not communicated from laboratory to clinician
  4. Varies - Communication of this type of reclassification from laboratory to clinician varies between laboratory geneticists