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Table 1 The comparison of transcriptomic biomarkers between fatal and nonfatal C-IRIS

From: Transcriptomic biomarker pathways associated with death in HIV-infected patients with cryptococcal meningitis

Gene Fatal C-IRIS group C-IRIS survivor group, earlier arm C-IRIS survivor group, deferred arm
Symbol R for VIP VIP rank R for VIP VIP rank R for VIP VIP rank
LIMK1 − 0.0116 − − − − − 0.0054 + + + + 0.015 + + + +
ALOX5 − 0.0101 − − − − 0.0026  + +  0.0102  + + + 
CTSC − 0.0087 − − − − 0.0056  + + + +  0.0137  + + + + 
IL17REL − 0.0092 − − − − 0.0033  + +  0.0074  + + 
TLR10 − 0.0089 − − − − 0.0027  + +  0.012  + + + 
C3AR1 − 0.0086 − − − 0.0058  + + + +  0.012  + + + 
CTSD − 0.0064 − − − 0.0038  + + +  0.0054  + + 
CTSK − 0.0086 − − − 0.0045  + + +  0.0103  + + + 
DEFB115 − 0.007 − − − 0.0057  + + + +  0.0122  + + + 
IL17D − 0.0068 − − − 0.0036  + +  0.0111  + + + 
ITGA7 − 0.0077 − − − 0.0058  + + + +  0.0086  + + 
ITGB2 − 0.0067 − − − 0.0052  + + +  0.0086  + + 
JAG1 − 0.0085 − − − 0.0034  + +  0.011  + + + 
SIGLEC10 − 0.0074 − − − 0.0065  + + + +  0.0118  + + + 
ALPL − 0.0044 − − 0.0063  + + + +  0.0103  + + + 
CASP5 − 0.0042 − − 0.0045  + + +  0.0121  + + + 
DEFA5 − 0.0044 − − 0.0047  + + +  0.0047  + 
ITGAX − 0.0061 − − 0.0069  + + + + +  0.0106  + + + 
NOD2 − 0.0043 − − 0.0043  + + +  0.0054  + + 
NOTCH2 − 0.0045 − − 0.0048  + + +  0.0063  + + 
NOX1 − 0.004 − − 0.0048  + + +  0.0044  + 
SIGLEC5 − 0.0044 − − 0.0037  + + +  0.0084  + + 
SIGLEC7 − 0.0057 − − 0.0047  + + +  0.0091  + + + 
BEX1 − 0.0033 0.0027  + +  0.0026  + 
CASP2 − 0.0034 0.0038  + + +  0.0063  + + 
ITGA5 − 0.0034 0.0056  + + + +  0.0043  + 
SIRPA − 0.0018 0.0038  + + +  0.007  + + 
IL1RAP 0.0146  + + + + + +  − 0.002 − 0.0071 − −
MMP20 0.0117  + + + + +  − 0.0037 − − − 0.0086 − −
ALOX5AP 0.0087  + + + +  − 0.0035 − − − 0.0073 − −
CCL1 0.0103  + + + +  − 0.004 − − − − 0.0079 − −
CD55 0.0089  + + + +  − 0.0005   − 0.0041
CLEC4D 0.0102  + + + +  − 0.0027 − − − 0.0055 − −
CLEC4E 0.0106  + + + +  − 0.0049 − − − − 0.0068 − −
CLEC5A 0.0091  + + + +  − 0.0032 − − − 0.004
F2RL2 0.0088  + + + +  − 0.0011 − 0.0058 − −
FADD 0.0102  + + + +  − 0.0037 − − − − 0.0071 − −
FAM65B 0.0091  + + + +  − 0.0006 − 0.0029
IFNAR1 0.0094  + + + +  − 0.0018 − 0.0037
IL18R1 0.0106  + + + +  − 0.0018 − 0.0032
IL18RAP 0.0101  + + + +  − 0.0016 − 0.0049
IL1R1 0.01  + + + +  − 0.0019 − 0.0052
IRAK3 0.0088  + + + +  − 0.0007 − 0.0042
KLKP1 0.0102  + + + +  − 0.0038 − − − − 0.0064 − −
LILRB5 0.0106  + + + +  − 0.0013 − 0.006 − −
TLR4 0.0096  + + + +  − 0.003 − − − 0.0046
CASP4 0.0065  + + +  − 0.003 − − − 0.0021
CD59 0.0082  + + +  − 0.0003   − 0.0003  
CLEC2L 0.0063  + + +  − 0.0044 − − − − 0.0102 − − −
CXCR1 0.0065  + + +  − 0.0011 − 0.0004  
EXOSC4 0.0081  + + +  − 0.0018 − 0.002
FAM188A 0.0076  + + +  − 0.0031 − − − 0.0049
IFNGR1 0.0066  + + +  − 0.0002   − 0.0017  
IL17F 0.0086  + + +  − 0.0028 − − − 0.0043
IL1R2 0.0084  + + +  − 0.0006   − 0.0054 − −
KLF2 0.0072  + + +  0.0018 + − 0.0025
KLF6 0.0064  + + +  − 0.0008 − 0.0022
MMP8 0.0068  + + +  − 0.0006   − 0.006 − −
CLEC4F 0.0039  + +  − 0.0036 − − − 0.0065 − −
IFRD1 0.005  + +  0.0009  +  − 0.0028
IL1RL1 0.0048  + +  − 0.0032 − − − 0.0045
IL1RN 0.0049  + +  − 0.0028 − − − 0.0016  
MMP9 0.0057  + +  0.0004   − 0.0042
MOSPD2 0.0044  + +  0.0001   − 0.0019
TLR2 0.0059 + + − 0.0007   − 0.0006  
HIV_RNA 0.0017 + − 0.0018 − 0.0015  
IL1RL2 0.0032 + 0.0023 + + − 0.0011  
SIGLEC9 0.0023 + 0.003 + + 0.0038  + 
IFNAR2 0.0008   0.0025 + + 0.0019  + 
NLRP3 − 0.0009 0.0054 + + + + 0.0079  + + 
  1. Number of “−” is a visual representation for predictive importance strength that the following transcript's expression is negatively associated with occurrence of IRIS events. One “−” is equal 0.7 on VIP scale
  2. Number of “+” is a visual representation for predictive importance strength that the following transcript’s expression is positively associated with occurrence of IRIS events. One “+” is equal 0.7 on VIP scale
  3. VIP variable importance in the projection values, R for VIP Correlation Coefficient of Least Square Mean for VIP