Fig. 3

UCSC Genome browser visualization of landscape surrounding TNFAIP3 locus. The yellow vertical line indicates position of the index SNP (rs5029939). Black horizontal bar at the top represents the haplotype blocks of the associated SSc-risk SNPs. The subsequent tracks as progress down are the bigWig files provided by Cistrome (hg38) for H3K27ac, H3K4me1, and H3K4me3 marks in B cells, fibroblasts, HUVECs, monocytes, and T cells. Gene annotation set from GENCODE v32 is presented below histone tracks. Beneath that, the two rows of black vertical lines depict DNase hypersensitivity clusters in 95 cell types from ENCODE and transcription factor ChIP clusters of 340 factors from ENCODE. SNPedia SNPs are presented at the bottom