Fig. 1

Landscape around four example IA-associated LD blocks showing enhancer marks in three cell types. HUVECs in blue, fibroblasts (lung) in green, SMCs in purple. IA-associated LD block in orange, index SNP is yellow line. “†” denotes significance. Relative height of ChIP-seq peaks all scaled from 0–10 in Genome Browser. A Genome browser screenshot showing the IA-associated LD block identified by the intergenic tap SNP rs1429412 near ANKRD44. All three marks (H3K27ac, H3K4me1, and H3K9ac) were present for both HUVECs and fibroblasts. B Genome browser screenshot showing the IA-associated LD block for the IL6 locus identified by the intronic tag SNP, rs1800796. All three marks are present for HUVECs. C Genome browser screenshot showing the IA-associated LD block identified by the intergenic tag SNP rs10757278 near CDKN2B-AS1. All three marks were present for HUVECs. D Genome browser screenshot showing the IA-associated LD block for the FGD6 locus identified by intronic tag SNP, rs6538595. All three marks were present for HUVECs