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Table 3 Gene ontology analysis using PANTHER

From: Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: Synchronous and differential responses

Pathways

p-valuea Bystander

p-value Irradiated

Inflammation mediated by chemokine and cytokine signaling pathway

6.44 × 10-4

NSb

Apoptosis signaling pathway

3.29 × 10-3

3.46 × 10-4

Plasminogen activating cascade

5.92 × 10-3

5.61 × 10-3

Angiogenesis

2.90 × 10-2

NS

Toll receptor signaling pathway

6.46 × 10-2

NS

TGF-beta signaling pathway

6.51 × 10-2

NS

p53 pathway

NS

3.87 × 10-3

Biological Process

  

Immunity and defense

3.42 × 10-10

2.30 × 10-5

Signal transduction

1.54 × 10-9

5.41 × 10-6

Cell proliferation and differentiation

8.99 × 10-9

5.74 × 10-6

Ligand-mediated signaling

1.72 × 10-7

6.83 × 10-4

Intracellular signaling cascade

1.29 × 10-6

2.43 × 10-3

NF-kappaB cascade

2.89 × 10-6

4.05 × 10-5

Cell communication

7.67 × 10-6

NS

Granulocyte-mediated immunity

1.51 × 10-5

1.36 × 10-5

Cell surface receptor mediated signal transduction

2.40 × 10-5

1.68 × 10-5

Apoptosis

2.73 × 10-5

2.23 × 10-5

Inhibition of apoptosis

2.81 × 10-4

2.51 × 10-4

Macrophage-mediated immunity

5.77 × 10-4

4.14 × 10-3

Mesoderm development

8.92 × 10-4

NS

Cytokine and chemokine mediated signaling pathway

2.58 × 10-3

3.76 × 10-4

Cell cycle control

NS

4.60 × 10-4

Developmental processes

NS

1.65 × 10-3

Molecular Function

  

Signaling molecule

6.54 × 10-11

2.29 × 10-6

Cytokine

3.22 × 10-5

3.32 × 10-4

Chemokine

8.39 × 10-5

1.68 × 10-2

  1. a p-values are Bonferroni-corrected
  2. b NS: not statistically significant (p > 0.05).