From: Genotator: A disease-agnostic tool for genetic annotation of disease
Gene | Score | Literature Support | Reference | WRW Mention |
---|---|---|---|---|
LRRK2 | 105.1 | Frequency of LRRK2 mutations in early-and late-onset Parkinson disease. | [42] | Y |
MAPT | 60.8 | Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy. | [43] | Y |
SNCA | 59.8 | Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. | [44] | Y |
PARK2 | 59.6 | Case-control study of the parkin gene in early-onset Parkinson disease. | [45] | Y |
APOE | 34.7 | Phenotypic associations of tau and ApoE in Parkinson's disease. | [46] | Â |
GBA | 21.4 | Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset. | [47] | Y |
BDNF | 19.5 | BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease. | [48] | Â |
DRD2 | 18.7 | Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease. | [49] | Â |
MAOB | 17.1 | Association of variations in monoamine oxidases A and B with Parkinson's disease subgroups. | [50] | Â |
PINK1 | 16.8 | Parkin and PINK1 mutations in early-onset Parkinson's disease: comprehensive screening in publicly available cases and control. | [51] | Y |