Table 3 Association of apoptosis SNPs with aggressive prostate cancer
Marker (Alleles and position) | Allele | Cases N (%) | Controls N (%) | OR (95%CI) | Adj OR (95%CI)* | p value | Bonf. p value | p trend | Permut. p value |
|---|---|---|---|---|---|---|---|---|---|
AKT3 | CC | 295 (42.9) | 244 (50.0) | 1.00 (reference) | 1.00 (reference) | 0.065 | 1.000 | 0.028 | 1.000 |
rs10157763 | TC | 307 (44.7) | 192 (39.3) | 1.31 (1.02-1.67) | 1.33 (1.04-1.71) | 0.027 | Â | Â | Â |
C240321082T | TT | 75 (10.9) | 45 (9.2) | 1.21 (0.82-1.78) | 1.39 (0.92-2.09) | 0.344 | Â | Â | Â |
| Â | TC + TT | 382 (55.6) | 237 (48.6) | 1.32 (1.04-1.66) | 1.34 (1.06-1.70) | 0.020 | 1.000 | Â | 0.943 |
AKT3 | GG | 438 (63.8) | 345 (70.7) | 1.00 (reference) | 1.00 (reference) | 0.005 | 0.853 | 0.038 | 0.493 |
rs10927067 | AG | 227 (33.0) | 119 (24.4) | 1.50 (1.15-1.95) | 1.51 (1.16-1.96) | 0.002 | Â | Â | Â |
G240249285A | AA | 20 (2.9) | 19 (3.9) | 0.83 (0.44-1.58) | 0.82 (0.43-1.57) | 0.568 | Â | Â | Â |
| Â | AG + AA | 247 (36.0) | 138 (28.3) | 1.43 (1.12-1.84) | 1.41 (1.10-1.82) | 0.005 | 0.977 | Â | 0.511 |
AKT3 | TT | 483 (70.3) | 380 (77.9) | 1.00 (reference) | 1.00 (reference) | 0.002 | 0.356 | 0.023 | 0.250 |
rs12031994 | TC | 192 (27.9) | 94 (19.3) | 1.61 (1.21-2.13) | 1.61 (1.22-2.14) | 0.009 | Â | Â | Â |
T240243350C | CC | 13 (1.9) | 14 (2.9) | 0.73 (0.34-1.57) | 0.73 (0.34-1.57) | 0.422 | Â | Â | Â |
| Â | TC + CC | 205 (29.8) | 108 (22.1) | 1.51 (1.15-1.98) | 1.50 (0.15-1.96) | 0.003 | 0.548 | Â | 0.372 |
AKT3 | GG | 436 (63.5) | 341 (69.9) | 1.00 (reference) | 1.00 (reference) | 0.030 | 1.000 | 0.068 | 0.984 |
rs2125230 | AG | 231 (33.6) | 129 (26.4) | 1.40 (1.09-1.81) | 1.40 (1.08-1.82) | 0.010 | Â | Â | Â |
G240211889A | AA | 21 (3.1) | 18 (3.7) | 0.91 (0.48-1.74) | 0.91 (0.48-1.74) | 0.781 | Â | Â | Â |
| Â | AG + AA | 252 (36.7) | 147 (30.1) | 1.35 (1.06-1.73) | 1.34 (1.05-1.72) | 0.017 | 1.000 | Â | 0.938 |
AKT3 | GG | 296 (43.1) | 238 (48.8) | 1.00 (reference) | 1.00 (reference) | 0.083 | 1.000 | 0.027 | 1.000 |
rs2125231 | AG | 314 (45.7) | 203 (41.6) | 1.24 (0.97-1.59) | 1.25 (0.98-1.60) | 0.082 | Â | Â | Â |
G240088340A | AA | 75 (10.9) | 42 (8.6) | 1.43 (0.95-2.17) | 1.44 (0.95-2.18) | 0.087 | Â | Â | Â |
| Â | AG + AA | 389 (56.6) | 245 (50.2) | 1.29 (1.02-1.63) | 1.28 (1.01-1.62) | 0.031 | 1.000 | Â | 0.992 |
AKT3 | CC | 295 (42.9) | 243 (49.8) | 1.00 (reference) | 1.00 (reference) | 0.060 | 1.000 | 0.022 | 1.000 |
rs2345994 | TC | 312 (45.4) | 195 (40.0) | 1.32 (1.03-1.69) | 1.32 (1.03-1.70) | 0.028 | Â | Â | Â |
C240258316T | TT | 78 (11.4) | 45 (9.2) | 1.43 (0.95-2.14) | 1.44 (0.95-2.16) | 0.084 | Â | Â | Â |
| Â | TC + TT | 390 (56.8) | 240 (49.2) | 1.32 (1.05-1.67) | 1.35 (1.06-1.70) | 0.018 | 1.000 | Â | 0.946 |
AKT3 | CC | 435 (63.3) | 348 (71.3) | 1.00 (reference) | 1.00 (reference) | 0.009 | 1.000 | 0.029 | 0.714 |
rs4132509 | AC | 227 (33.0) | 121 (24.8) | 1.50 (1.15-1.95) | 1.51 (1.16-1.96) | 0.002 | Â | Â | Â |
C240269125A | AA | 18 (2.6) | 16 (3.3) | 0.90 (0.45-1.79) | 0.88 (0.44-1.75) | 0.764 | Â | Â | Â |
| Â | AC + AA | 245 (35.7) | 137 (28.1) | 1.43 (1.11-1.84) | 1.44 (1.11-1.85) | 0.005 | 1.000 | Â | 0.581 |
BCL2L14 | GG | 436 (63.5) | 343 (70.3) | 1.00 (reference) | 1.00 (reference) | 0.041 | 1.000 | 0.025 | 0.998 |
rs885720 | AG | 231 (33.6) | 131 (26.8) | 1.39 (1.07-1.79) | 1.39 (1.08-1.80) | 0.012 | Â | Â | Â |
G12139366A | AA | 21 (3.1) | 14 (2.9) | 1.18 (0.59-2.25) | 1.20 (0.60-2.39) | 0.639 | Â | Â | Â |
| Â | AG + AA | 252 (36.7) | 145 (29.7) | 1.37 (1.07-1.76) | 1.37 (1.07-1.76) | 0.013 | 1.000 | Â | 0.843 |
CARD8 | CC | 462 (67.2) | 362 (74.2) | 1.00 (reference) | 1.00 (reference) | 0.016 | 1.000 | 0.005 | 0.882 |
rs10405717 | TC | 202 (29.4) | 111 (22.7) | 1.45 (1.11-1.90) | 1.45 (1.11-1.90) | 0.007 | Â | Â | Â |
C53443620T | TT | 21 (3.1) | 10 (2.0) | 1.70 (0.79-3.68) | 1.70 (0.79-3.68) | 0.173 | Â | Â | Â |
| Â | TC + TT | 223 (32.5) | 121 (24.8) | 1.45 (1.12-1.89) | 1.47 (1.13-1.91) | 0.005 | 0.754 | Â | 0.459 |
IKBKE | TT | 251 (36.5) | 209 (42.8) | 1.00 (reference) | 1.00 (reference) | 0.008 | 1.000 | 0.003 | 0.682 |
rs11578093 | TG | 332 (48.3) | 233 (47.7) | 1.19 (0.93-1.52) | 1.17 (0.91-1.50) | 0.177 | Â | Â | Â |
T203059049G | GG | 102 (6.0) | 46 (9.4) | 1.85 (1.25-2.74) | 1.81 (1.22-2.69) | 0.002 | Â | Â | Â |
| Â | TG + GG | 434 (63.2) | 279 (57.2) | 1.31 (1.03-1.66) | 1.27 (1.00-1.62) | 0.027 | 1.000 | Â | 0.982 |
IKBKE | CC | 502 (73.1) | 341 (69.9) | 1.00 (reference) | 1.00 (reference) | 0.048 | 1.000 | 0.076 | 1.000 |
rs1539243 | TC | 172 (25.0) | 125 (25.6) | 0.93 (0.71-1.22) | 0.95 (0.73-1.24) | 0.622 | Â | Â | Â |
C203036182T | TT | 14 (2.0) | 22 (4.5) | 0.43 (0.22-0.86) | 0.44 (0.22-0.88) | 0.016 | Â | Â | Â |
| Â | TC + TT | 186 (27.1) | 147 (30.1) | 0.86 (0.66-1.11) | 0.88 (0.68-1.13) | 0.244 | 1.000 | Â | 1.000 |
PIK3CB | TT | 215 (31.3) | 131 (26.8) | 1.00 (reference) | 1.00 (reference) | 0.060 | 1.000 | 0.021 | 1.000 |
rs500687 | TC | 334 (48.6) | 234 (48.0) | 0.87 (0.66-1.14) | 0.87 (0.66-1.14) | 0.318 | Â | Â | Â |
T139942901C | CC | 134 (19.5) | 121 (24.8) | 0.67 (0.49-0.94) | 0.66 (0.48-0.92) | 0.019 | Â | Â | Â |
| Â | TC + CC | 468 (68.1) | 355 (72.7) | 0.81 (0.62-1.04) | 0.80 (0.62-1.03) | 0.099 | 1.000 | Â | 1.000 |
RAF1 | TT | 508 (73.9) | 377 (77.3) | 1.00 (reference) | 1.00 (reference) | 0.010 | 1.000 | 0.473 | 0.764 |
rs13060691 | TG | 167 (24.3) | 90 (18.4) | 1.38 (1.03-1.84) | 1.38 (1.03-1.84) | 0.030 | Â | Â | Â |
T12653013G | GG | 10 (1.5) | 16 (3.3) | 0.44 (0.20-0.97) | 0.45 (0.20-1.01) | 0.060 | Â | Â | Â |
| Â | TG + GG | 177 (25.8) | 106 (21.7) | 1.24 (0.94-1.63) | 1.24 (0.94-1.63) | 0.123 | 1.000 | Â | 1.000 |