Table 4 Top GO clusters enriched in top 300 differentially expressed genes associated with predicted response to docetaxel
From: Predicting drug response of tumors from integrated genomic profiles by deep neural networks
GO ID | GO term | Num. genes | P-value |
|---|---|---|---|
Cluster 1 (enrichment score: 10.89) | |||
GO:0007049 | cell cycle | 40 | 1.13 × 10−10 |
GO:0022402 | cell cycle process | 33 | 3.51 × 10− 10 |
GO:0000279 | M phase | 32 | 1.01 × 10−15 |
Cluster 2 (enrichment score: 3.96) | |||
GO:0000166 | nucleotide binding | 56 | 1.95 × 10−4 |
GO:0032553 | ribonucleotide binding | 54 | 2.74 × 10−6 |
GO:0032555 | purine ribonucleotide binding | 54 | 2.74 × 10−6 |
Cluster 3 (enrichment score: 3.45) | |||
GO:0000278 | mitotic cell cycle | 26 | 1.01 × 10− 9 |
GO:0051726 | regulation of cell cycle | 15 | 8.48 × 10−4 |
GO:0007346 | regulation of mitotic cell cycle | 12 | 3.09 × 10−5 |
Cluster 4 (enrichment score: 2.47) | |||
GO:0051327 | M phase of meiotic cell cycle | 8 | 9.46 × 10−4 |
GO:0007126 | meiosis | 8 | 9.46 × 10−4 |
GO:0051321 | meiotic cell cycle | 8 | 1.07 × 10− 3 |
Cluster 5 (enrichment score: 2.07) | |||
GO:0051276 | chromosome organization | 13 | 8.64 × 10−2 |
GO:0007059 | chromosome segregation | 6 | 9.34 × 10− 3 |
GO:0000070 | mitotic sister chromatid segregation | 5 | 2.45 × 10− 3 |