Fig. 4

Top three ranked drug targets with their interactions with other nodes in corresponding clusters in cell-line integrated network and the survival analysis on them. In (a) and (b), cube nodes indicate known targets while the circle nodes indicate other genes. Red and blue lines indicate positive and negative correlations respectively. Line shade indicates correlation intensity. Nodes are placed in a clockwise order by their degrees. a Top rated Drug targets ‘PGK1’ and the subnetwork of its cluster. PGK1 is the node that has the highest number of connections. b Second and third rated Drug targets ‘POLE2’, ‘HMMR’ and the corresponding subnetwork of their common cluster. Yellow highlighted genes are common genes between HMMR and POLE2. RAD51 is the node that has the highest number of connections. c High expression of PGK1 versus Low expression of PGK1 survival curves. d High expression of HMMR versus Low expression of HMMR survival curves. e High expression of POLE2 versus Low expression of POLE2 survival curves