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Table 5 Expression of most abundantly expressed circRNAs and their parental transcripts in EndoC-βH1 cells treated with diabetes-related stresses

From: Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

Transcript

Treatment

p-value

Median (IQR)

CAMSAP1

Control

 

1.11 (0.95–1.39)

2.5 mM glucose

0.313

1.03 (0.92–1.05)

25 mM glucose

0.444

0.96 (0.95–1.17)

Control

 

0.92 (0.89–1.06)

1% O2

0.694

0.97 (0.73–1.04)

3% O2

0.347

0.88 (0.63–0.99)

Control

 

1.05 (0.95–1.08)

Palmitic acid

0.062

0.89 (0.77–0.94)

Control

 

0.93 (0.25–1.21)

Cytokines

0.635

0.95 (0.90–0.99)

CircCAMSAP1

Control

 

0.84 (0.79–1.11)

2.5 mM glucose

0.762

1.02 (0.75–1.12)

25 mM glucose

0.681

0.92 (0.78–1.29)

Control

 

0.98 (0.92–1.14)

1% O2

0.136

0.89 (0.76–0.93)

3% O2

0.292

0.83 (0.63–1.07)

Control

 

1.04 (1.02–1.23)

Palmitic acid

0.090

0.82 (0.65–1.00)

Control

 

0.77 (0.27–1.14)

Cytokines

0.555

0.99 (0.69–1.02)

CIRBP

Control

 

1.06 (0.83–1.08)

2.5 mM glucose

0.080

1.38 (1.10–1.53)

25 mM glucose

0.077

1.30 (1.14–1.56)

Control

 

1.01 (0.99–1.09)

1% O2

0.146

0.79 (0.39–0.97)

3% O2

0.129

0.84 (0.74–1.02)

Control

 

0.88 (0.65–1.09)

Palmitic acid

0.907

0.91 (0.64–1.15)

Control

 

0.90 (0.03–1.34)

Cytokines

0.593

0.95 (0.93–1.06)

CircCIRBP

Control

 

0.77 (0.61–1.42)

2.5 mM glucose

0.844

0.86 (0.32–1.37)

25 mM glucose

0.652

0.77 (0.72–0.94)

Control

 

1.10 (1.00–1.23)

1% O2

0.955

0.86 (0.56–2.00)

3% O2

0.726

0.89 (0.68–1.48)

Control

 

0.75 (0.72–1.04)

Palmitic acid

0.021

1.69 (1.30–1.98)

Control

 

1.17 (1.00–1.33)

Cytokines

0.180

0.73 (0.69–1.06)

RPH3AL

Control

 

1.05 (0.93–1.06)

2.5 mM glucose

0.503

0.99 (0.75–1.07)

25 mM glucose

0.441

0.93 (0.80–1.08)

Control

 

1.09 (1.06–1.37)

1% O2

0.357

1.55 (1.04–1.56)

3% O2

0.205

1.32 (1.28–1.81)

Control

 

0.95 (0.87–0.99)

Palmitic acid

0.102

0.84 (0.70–0.87)

Control

 

0.98 (0.02–1.01)

Cytokines

0.354

1.02 (0.91–1.12)

CircRPH3AL

Control

 

1.00 (0.45–1.00)

2.5 mM glucose

0.941

0.85 (0.58–0.97)

25 mM glucose

0.867

0.76 (0.73–0.86)

Control

 

1.09 (1.06–1.37)

1% O2

0.357

1.55 (1.04–1.56)

3% O2

0.205

1.32 (1.28–1.81)

Control

 

1.66 (1.32–1.85)

Palmitic acid

0.022

0.97 (0.95–1.11)

Control

 

0.68 (0.47–0.77)

Cytokines

0.295

0.97 (0.55–1.02)

RHOBTB3

Control

 

1.24 (1.23–1.31)

2.5 mM glucose

0.188

1.11 (1.00–1.27)

25 mM glucose

0.117

1.20 (0.72–1.14)

Control

 

0.95 (0.69–1.06)

1% O2

0.949

0.97 (0.77–0.98)

3% O2

0.353

0.67 (0.65–0.93)

Control

 

0.80 (0.72–0.90)

Palmitic acid

0.003

1.18 (1.15–1.21)

Control

 

1.17 (0.29–1.35)

Cytokines

0.186

1.59 (1.22–1.72)

CircRHOBTB3

Control

 

0.74 (0.73–1.00)

2.5 mM glucose

0.836

0.89 (0.65–1.02)

25 mM glucose

0.351

0.77 (0.57–0.78)

Control

 

1.04 (0.72–1.08)

1% O2

0.182

0.78 (0.74–0.78)

3% O2

0.288

0.79 (0.77–0.86)

Control

 

1.16 (0.99–1.27)

Palmitic acid

0.306

1.03 (0.83–1.13)

Control

 

1.01 (0.95–1.08)

Cytokines

0.628

0.97 (0.89–1.06)

ZKSCAN1

Control

 

1.24 (1.18–1.33)

2.5 mM glucose

0.632

1.23 (1.05–1.87)

25 mM glucose

0.997

1.23 (1.16–1.36)

Control

 

0.93 (0.86–1.08)

1% O2

0.388

1.06 (0.94–1.12)

3% O2

0.218

0.72 (0.66–0.98)

Control

 

0.50 (0.39–0.55)

Palmitic acid

0.001

1.01 (0.94–1.12)

Control

 

1.29 (0.24–1.33)

Cytokines

0.378

1.30 (1.27–1.35)

CircZKSCAN1

Control

 

0.86 (0.81–1.17)

2.5 mM glucose

0.490

0.91 (0.83–1.17)

25 mM glucose

0.505

0.88 (0.83–1.28)

Control

 

1.11 (0.99–1.42)

1% O2

0.060

1.65 (1.41–1.79)

3% O2

0.631

1.24 (1.02–1.57)

Control

 

1.01 (0.81–1.45)

Palmitic acid

0.252

0.83 (0.75–0.91)

Control

 

1.05 (0.10–1.13)

Cytokines

0.292

1.16 (1.13–1.18)

  1. We assessed the effect of diabetes-related cellular stresses (low/high glucose, elevated fatty acid, hypoxia and exposure to pro-inflammatory cytokines) on the expression of the 5 most abundant islet circRNAs in the Endo-βH1 human beta cell line. IQR = interquartile range. Results meeting the threshold for 4 test conditions are given in bold underlined type, those presenting nominal associations only are indicated in bold italic type
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BMC Medical Genomics

ISSN: 1755-8794

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