Table 3 Analysis of the association between diabetes risk and single nucleotide polymorphism of STAT4
From: Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population
SNP ID | Model | Genotype | Case | Control | Adjusted by age and gender | |
|---|---|---|---|---|---|---|
OR (95% CI) | p | |||||
rs3821236 | Allele | G | 521 | 574 | 1.00 | |
A | 479 | 428 | 1.23 (1.03–1.47) | 0.020* | ||
Genotype | AA | 113 | 93 | 1.51 (1.05–2.15) | 0.025* | |
AG | 253 | 242 | 1.30 (0.97–1.73) | 0.077 | ||
GG | 134 | 166 | 1.00 | |||
Dominant | AA-AG | 366 | 335 | 1.36 (1.03–1.78) | 0.029* | |
GG | 134 | 166 | 1.00 | |||
Recessive | AA | 113 | 93 | 1.28 (0.94–1.74) | 0.114 | |
AG-GG | 387 | 408 | 1.00 | |||
Log-additive | – | – | – | 1.23 (1.03–1.47) | 0.020* | |
rs11893432 | Allele | C | 517 | 560 | 1.00 | |
G | 483 | 442 | 1.18 (0.99–1.41) | 0.060 | ||
Genotype | GG | 116 | 98 | 1.40 (0.98–1.99) | 0.064 | |
GC | 251 | 246 | 1.21 (0.90–1.61) | 0.208 | ||
CC | 133 | 157 | 1.00 | |||
Dominant | GG-GC | 367 | 344 | 1.26 (0.96–1.66) | 0.098 | |
CC | 133 | 157 | 1.00 | |||
Recessive | GG | 116 | 98 | 1.24 (0.92–1.68) | 0.161 | |
GC-CC | 384 | 403 | 1.00 | |||
Log-additive | – | – | – | 1.18 (0.99–1.41) | 0.060 | |
rs11889341 | Allele | C | 645 | 669 | 1.00 | |
T | 355 | 329 | 1.12 (0.93–1.35) | 0.233 | ||
Genotype | TT | 53 | 51 | 1.16 (0.75–1.78) | 0.499 | |
TC | 249 | 227 | 1.22 (0.94–1.59) | 0.131 | ||
CC | 198 | 221 | 1.00 | |||
Dominant | TT-TC | 302 | 278 | 1.21 (0.94–1.56) | 0.134 | |
CC | 198 | 221 | 1.00 | |||
Recessive | TT | 53 | 51 | 1.04 (0.69–1.56) | 0.845 | |
TC-CC | 447 | 448 | 1.00 | |||
Log-additive | – | – | – | 1.13 (0.93–1.36) | 0.220 | |
rs7574865 | Allele | G | 653 | 673 | 1.00 | |
T | 347 | 327 | 1.09 (0.91–1.32) | 0.344 | ||
Genotype | TT | 49 | 47 | 1.14 (0.73–1.77) | 0.571 | |
TG | 249 | 233 | 1.17 (0.90–1.51) | 0.253 | ||
GG | 202 | 220 | 1.00 | |||
Dominant | TT-TG | 298 | 280 | 1.16 (0.90–1.49) | 0.247 | |
GG | 202 | 220 | 1.00 | |||
Recessive | TT | 49 | 47 | 1.05 (0.69–1.60) | 0.828 | |
TG-GG | 451 | 453 | 1.00 | |||
Log-additive | – | – | – | 1.10 (0.91–1.34) | 0.322 | |
rs897200 | Allele | T | 511 | 507 | 1.00 | |
C | 489 | 495 | 0.98 (0.82–1.17) | 0.823 | ||
Genotype | CC | 125 | 118 | 0.97 (0.68–1.37) | 0.846 | |
CT | 239 | 259 | 0.84 (0.62–1.14) | 0.260 | ||
TT | 136 | 124 | 1.00 | |||
Dominant | CC-CT | 364 | 377 | 0.88 (0.66–1.17) | 0.377 | |
TT | 136 | 124 | 1.00 | |||
Recessive | CC | 125 | 118 | 1.08 (0.81–1.45) | 0.594 | |
CT-TT | 375 | 383 | 1.00 | |||
Log-additive | – | – | – | 0.98 (0.82–1.17) | 0.822 | |