Fig. 1

Contrast sensitivity strongly correlates with susceptibility to form-deprivation myopia in mice. a Baseline refractive errors range from highly myopic to highly hyperopic in mice depending on the genetic background. Horizontal red lines show mean refractive errors for each strain, while each dot corresponds to mean refractive errors of individual animals. b Susceptibility to form-deprivation myopia in mice is determined by genetic background. Horizontal red lines identify means of induced myopia for each strain, while each dot represents a mean interocular difference between the treated eye and contralateral control eye for individual animals. c Contrast sensitivity in mice is determined by genetic background. Horizontal red lines identify means of contrast sensitivity for each strain, while each dot represents a mean contrast sensitivity for individual animals. d Baseline refractive error does not correlate with sensitivity to contrast. Linear regression showing lack of correlation between baseline refractive error and contrast sensitivity. r, Pearson’s correlation coefficient; P, Pearson’s correlation significance. e Susceptibility to form-deprivation myopia correlates with sensitivity to contrast. Linear regression showing correlation between form-deprivation myopia and contrast sensitivity. r, Pearson’s correlation coefficient; P, Pearson’s correlation significance. f Contrast sensitivity profiles in eight genetically different strains of mice. Contrast sensitivity was measured at 0.031, 0.064, 0.092, 0.103, 0.192, and 0.272 cycles/degree (cpd). Colors identify different strains of mice as shown at the bottom