Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression

Table 1 IA risk associated SNPs and the associated linkage disequilibrium blocks

Sentinel SNP	SNP Location	Nearest Gene	LD Block (hg38)	Length (bp)
rs3767137	Intronic	HSPG2	chr1:21834230–21841817	7587
rs1800255	Exonic	COL3A1	chr2:188976887–189003156	26,269
rs1429412	Intergenic	ANKRD44	chr2:197283467–197358397	74,930
rs700651	Intronic	BOLL	chr2:197676674–197766990	90,316
rs6841581	Intergenic	EDNRA	chr4:147444187–147493499	49,312
rs251124	Intronic	VCAN	chr5:83509605–83530435	20,830
rs4628172	Intronic	AGMO	chr7:15454259–15466904	12,645
rs1800796	Intronic	IL6	chr7:22726627–22732119	5492
rs42524	Exonic	COL1A2	chr7:94413927–94420044	6117
rs10958409	Intergenic	–	chr8:54397171–54415556	18,385
rs9298506	Intergenic	–	chr8:54509054–54549764	40,710
rs2891168	Intronic	CDKN2B-AS1	chr9:22072265–22125504	53,239
rs10757278	Intergenic	CDKN2B-AS1	chr9:22077086–22125504	48,418
rs6538595	Intronic	FGD6	chr12:95095355–95123067	27,712
rs4934	Exonic	SERPINA3	chr14:94612340–94614466	2126
rs1132274	Exonic	RRBP1	chr20:17613385–17619469	6084

Bolded SNPs were chosen as examples in Fig. 1, Fig. 2, and Additional file 1: Fig. S1
hg, human genome; IA, intracranial aneurysm; rs, reference SNP cluster ID; SNP, single nucleotide polymorphism; chr, chromosome; LD, linkage disequilibrium

ISSN: 1755-8794