Fig. 4
From: A link between mitochondrial damage and the immune microenvironment of delayed onset muscle soreness
Characteristics of immune infiltration in skeletal muscle of DOMS patients. (A) Boxplot of scores based on single-sample gene set enrichment analysis (ssGSEA) in the validation cohort (left); boxplot of CIBERSORT-calculated immune cell proportion scores (right). Red represents non-DOMS patients. Blue represents patients with DOMS. ***p < 0.001, **p < 0.01, *p < 0.05, ns = 1 (independent sample Kruskal–Wallis test). Proportions of immune cells in the DOMS (left) and non-DOMS (right) groups in the validation cohort. (C–F) Comparison of infiltration by 28 immune cells between the high and low expression groups of four hub genes: (C) AMPK, (D) ARMCX1, (E) PGC1-α, and (F) SLC25A25. (G) Four hub genes (AMPK, ARMCX1, PGC1-α, and SLC25A25) were analysed for Spearman correlation with 28 immune cells. (H) Analysis of Spearman correlation between mitochondria-related gene (TCA cycle) and 28 immune cells