Fig. 5
From: A link between mitochondrial damage and the immune microenvironment of delayed onset muscle soreness
Mitochondrial respiratory chain complex damage and mtDNA expression abnormality in skeletal muscle induced by DOMS. (A) Heatmap showing significant upregulation of respiratory chain complexes (I–II) and abnormal mtDNA expression of DOMS in the validation cohort. (B) Heatmap of Spearman correlation values between respiratory chain complexes (I–II), mtDNA genes, and immune cells in DOMS from the validation cohort. (C) Inference of inflammatory factors and mtDNA using Bayesian neural networks. Scale bar = 50 mm. (D) Immunohistochemical staining for IL-6 was performed on paraffin-embedded skeletal muscle specimens from rats. (E) Heatmap of Spearman correlation values between mtDNA genes and four hub genes (AMPK, PGC1-α, SLC25A25, and ARMCX1) in DOMS from the validation cohort