Fig. 6
From: A link between mitochondrial damage and the immune microenvironment of delayed onset muscle soreness
PGC1-α is a major biomarker of mitochondrial dysfunction and the immune microenvironment in DOMS. (A). Correlations of four hub genes with mtDNA, apoptosis, and SLC25a family. Colour shows the Pearson’s correlation coefficient between hub genes (AMPK, PGC1-α, SLC25A25, and ARMCX1) and mtDNA, apoptosis, and SLC25a family-related genes; blue shows positive correlation (Pearson’s R < 0), red indicates negative correlation (Pearson’s R > 0). The Mantel test was used for statistical analysis; yellow lines indicate a p-value < 0.01, and green lines indicate 0.01 < p < 0.05. PGC1-α shows a strong correlation. (B, C) Construction of Bayesian networks using mitochondrial genes. The related immune pathway showed that PGC1-α is the main regulatory gene