Fig. 4
From: Genetic and molecular dynamics analysis of two variants of the COL4A5 gene causing Alport syndrome
Evolutionary conservation analysis of aberrant amino acid residues caused by COL4A5 gene variants across species. (A) The evolutionary conservation of amino acid residues that have been altered by p.D1472Mfs has been observed across various species. The NCBI accession numbers for these species are as follows: Homo sapiens (NP_000486.1), Mus musculus (001156627.1), Danio rerio (NP_001116702.1), Canis lupus familiaris (NP_001002979.1), Xenopus tropicalis (XP_004916922.2), Macaca mulatta (XP_014983488.2), and Gallus gallus (XP_015134092.2). The location of the code shift variation is indicated by a red arrow. (B) The present study examines the evolutionary preservation of amino acid residues that have been modified by the insertion of DYFVEI at position P1432_G1433 across various species. The NCBI accession numbers for the respective species are as follows: Homo sapiens (NP_000486.1), Danio rerio (NP_001116702.1), Macaca mulatta (XP_014983488.2), Xenopus tropicalis (XP_004916922.2), and Gallus gallus (XP_015134092.2). The asterisk (*) denotes the presence of inserted amino acids