Table 5 Relationship between SNP gene pattern and cognitive impairment
From: ApoE gene polymorphisms and metals and their interactions with cognitive function
SNP | Model | Genotype | β | Adjusted OR (confidence interval) | P | |
|---|---|---|---|---|---|---|
Reference | Alternate | |||||
rs429358 T>C | Co-dominant model | TT | TC | -0.054 | 0.947(0.618–1.451) | 0.803 |
|  |  |  | CC | -0.582 | 0.559(0.067–4.652) | 0.590 |
|  | dominant model | TT | TC + CC | -0.075 | 0.928(0.609–1.412) | 0.726 |
|  | Recessive model | TT + TC | CC | -0.573 | 0.564(0.068–4.688) | 0.596 |
|  | Over dominant model | TT + CC | TC | -0.050 | 0.952(0.621–1.457) | 0.820 |
rs7412 C>T | Co-dominant model | CC | CT | 0.253 | 1.288(0.859–1.933) | 0.221 |
|  |  |  | TT | 1.135 | 3.112(1.159–8.359) | 0.024 |
|  | dominant model | CC | CT + TT | 0.356 | 1.427(0.974–2.090) | 0.068 |
|  | Recessive model | CC + CT | TT | 1.092 | 2.979(1.112–7.978) | 0.030 |
|  | Over dominant model | CC + TT | TC | 0.222 | 1.249(0.834–1.872) | 0.281 |
rs7259620 G>A | Co-dominant model | GG | GA | 0.038 | 1.039(0.743–1.454) | 0.823 |
|  |  |  | AA | 0.462 | 1.588(1.007–2.504) | 0.047 |
|  | dominant model | GG | GA + AA | 0.147 | 1.158(0.849–1.581) | 0.354 |
|  | Recessive model | GG + GA | AA | 0.444 | 1.558(1.019–2.384) | 0.041 |
|  | Over dominant model | GG + AA | GA | -0.076 | 0.927(0.678–1.267) | 0.635 |
rs405509 T>G | Co-dominant model | TT | TG | 0.002 | 1.002(0.715–1.406) | 0.989 |
|  |  |  | GG | 0.438 | 1.550(0.992–2.420) | 0.054 |
|  | dominant model | TT | TG + GG | 0.121 | 1.129(0.827–1.541) | 0.444 |
|  | Recessive model | TT + TG | GG | 0.437 | 1.548(1.022–2.344) | 0.039 |
|  | Over dominant model | TT + GG | TG | -0.110 | 0.895(0.654–1.226) | 0.491 |