Table 1 Summary of genetic variants associated with exposure (obesity) and outcome (head and neck cancer)
From: Obesity and head and neck cancer risk: a mendelian randomization study
Variables | Source | Year | Searching | Sample size | Region | SNPs with significant (P < 5 × 10− 8) | SNPs without LD [r2, kb (0.01, 10,000) |
|---|---|---|---|---|---|---|---|
Exposures | Â | Â | Â | Â | Â | Â | Â |
 BMI | GWAS-Catlog | 2015 | Locke et al.14 | 339,224 | European | 4,971 | 84 |
 BMI adjust for smoking | GWAS-Catlog | 2017 | Justice et al.15 | 241,258 | European | 2,883 | 22 |
 WHR | GIANT | 2015 | Shungin et al.16 | 224,459 | European | 506 | 31 |
 WHR adjust for BMI | GWAS-Catlog | 2015 | Shungin et al.16 | 224,459 | European | 465 | 48 |
 WHR adjust for BMI in non-smoker | GWAS-Catlog | 2017 | Justice et al.15 | 241,258 | European | 1,537 | 4 |
 WHR adjust for BMI and smoking | GWAS-Catlog | 2017 | Justice et al.15 | 241,258 | European | 1,537 | 20 |
 Whole body fat mass | MRC IEU (UK Biobank) | 2018 | GWAS ID: ukb-b-19,393 | 454,137 | European | 60,088 | 435 |
 Lean body mass | GWAS-Catlog | 2017 | Medina-Gomez et al.17 | 8,327 | European | 308 | 47 |
 Trunk fat mass | MRC IEU (UK Biobank) | 2018 | GWAS ID: ukb-b-20,044 | 454,588 | European | 61,670 | 422 |
Outcomes | Â | Â | Â | Â | Â | Â | Â |
 Head and neck cancer | MRC IEU (UK Biobank) | 2021 | GWAS ID: ieu-b-4912 | 373,122 | European | NA | NA |
 Oral cavity cancer | MRC IEU (UK Biobank) | 2021 | GWAS ID: ieu-b-4961 | 372,373 | European | NA | NA |
 Oropharyngeal cancer | MRC IEU (UK Biobank) | 2021 | GWAS ID: ieu-b-4968 | 372,510 | European | NA | NA |
 Oral cavity and oropharyngeal cancer | MRC IEU (UK Biobank) | 20,211 | GWAS ID: ieu-b-4962 | 372,855 | European | NA | NA |