Table 2 The number of SNPs used for analysis and their pleiotropy, strength, and heterogeneity tests
From: Obesity and head and neck cancer risk: a mendelian randomization study
Outcome | Exposure | Uncorrelated pleiotropy | Correlated pleiotropy | Strength | Heterogeneity | |
Number of SNPs (non-MAF) | MR-Egger (Intercept, P) | F-statistic, R2 | MR-Egger (Q statistic, P) | IVW (Q statistic, P) | ||
Head and neck cancer | BMI | 78 | -0.0000, 0.8500 | 25.035, 0.6 | 69.4002, 0.6905 | 69.4362, 0.7179 |
BMI adjust for smoking | 20 | 0.0001, 0.4909 | 20.518, 0.2 | 21.2557, 0.2667 | 21.8396, 0.2923 | |
WHR | 28 | 0.0000, 0.7136 | 19.208, 0.2 | 23.4464, 0.6076 | 23.5842, 0.6533 | |
WHR adjust for BMI | 44 | 0.0000, 0.7505 | 21.091, 0.4 | 39.0745, 0.6001 | 39.1769, 0.6378 | |
WHR adjust for BMI in non-smoker | 4 | 0.0002, 0.6536 | 29.379, 0.1 | 0.9857, 0.6109 | 1.2584, 0.7390 | |
WHR adjust for BMI and smoking | 19 | 0.0001, 0.4517 | 24.229, 0.2 | 16.7629, 0.4705 | 17.3562, 0.4988 | |
Whole body fat mass | 399 | 0.0000, 0.337 | 24.037, 2.1 | 388.4259, 0.6113 | 389.3501, 0.6122 | |
Lean body mass | 44 | -0.0001, 0.1205 | 6.498, 3.4 | 30.0598, 0.9158 | 32.5710, 0.8765 | |
Trunk fat mass | 386 | 0.0000, 0.1656 | 24.154, 2.1 | 395.6752, 0.3296 | 397.6635, 0.3172 | |
Oral cavity cancer | BMI | 75 | 0.0000, 0.5877 | 25.654, 0.6 | 57.6927, 0.9052 | 57.9892, 0.9145 |
BMI adjust for smoking | 20 | 0.0001, 0.1563 | 21.181, 0.2 | 17.8527, 0.4654 | 20.0416, 0.3921 | |
WHR | 29 | 0.0001, 0.4294 | 19.039, 0.2 | 28.7347, 0.3739 | 29.4196, 0.3915 | |
WHR adjust for BMI | 44 | 0.0001, 0.2917 | 21.155, 0.4 | 31.2901, 0.8871 | 32.4302, 0.8802 | |
WHR adjust for BMI in non-smoker | 4 | 0.0003, 0.3651 | 29.379, 0.1 | 3.0021, 0.2229 | 5.0293, 0.1697 | |
WHR adjust for BMI and smoking | 19 | 0.0001, 0.1542 | 24.229, 0.2 | 12.9371, 0.7404 | 15.1609, 0.6509 | |
Whole body fat mass | 386 | -0.0000, 0.9999 | 24.785, 2.1 | 342.3921, 0.9376 | 342.3921, 0.9420 | |
Lean body mass | 43 | -0.0000, 0.5551 | 6.558, 3.4 | 29.6563, 0.9059 | 30.0104, 0.9168 | |
Trunk fat mass | 376 | 0.0000, 0.5103 | 24.92, 2.1 | 345.6535, 0.8507 | 346.0878, 0.8553 | |
Oropharyngeal cancer | BMI | 78 | -0.0000, 0.9903 | 24.704, 0.6 | 68.3080, 0.7230 | 68.3082, 0.7500 |
BMI adjust for smoking | 19 | 0.0000, 0.7971 | 20.928, 0.2 | 13.5383, 0.6995 | 13.6066, 0.7544 | |
WHR | 28 | 0.0000, 0.9531 | 18.955, 0.2 | 18.9115, 0.8401 | 18.9151, 0.8731 | |
WHR adjust for BMI | 44 | 0.0000, 0.5067 | 21.135, 0.4 | 42.8039, 0.4365 | 43.2611, 0.4602 | |
WHR adjust for BMI in non-smoker | 7 | 0.0000, 0.9478 | 29.39, 0.1 | 4.6050, 0.4660 | 4.6097, 0.5948 | |
WHR adjust for BMI and smoking | 19 | 0.0001, 0.3156 | 24.229, 0.2 | 19.0014, 0.3285 | 20.1968, 0.3218 | |
Whole body fat mass | 396 | 0.0000, 0.3228 | 24.103, 2.1 | 353.4590, 0.9296 | 354.4391, 0.9295 | |
Lean body mass | 44 | -0.0001, 0.0791 | 6.446, 3.4 | 35.4305, 0.7531 | 38.6684, 0.6595 | |
Trunk fat mass | 383 | 0.0000, 0.0709 | 24.239, 2.0 | 363.6304, 0.7307 | 366.9096, 0.7016 | |
Oral cavity and oropharyngeal cancer | BMI | 77 | -0.0000, 0.8766 | 25.265, 0.6 | 67.8745, 0.7076 | 67.8987, 0.7348 |
BMI adjust for smoking | 20 | 0.0000, 0.9455 | 20.518, 0.2 | 24.1838, 0.1491 | 24.1903, 0.1890 | |
WHR | 26 | 0.0001, 0.5159 | 19.709, 0.2 | 22.4942, 0.5498 | 22.9290, 0.5817 | |
WHR adjust for BMI | 41 | 0.0001, 0.1895 | 20.407, 0.4 | 41.0630, 0.3802 | 42.9405, 0.3463 | |
WHR adjust for BMI in non-smoker | 6 | 0.0001, 0.6145 | 29.59, 0.1 | 2.3738, 0.6674 | 2.6711, 0.7505 | |
WHR adjust for BMI and smoking | 16 | 0.0003, 0.1228 | 24.969, 0.2 | 10.9424, 0.6906 | 13.6399, 0.5530 | |
Whole body fat mass | 396 | 0.0000, 0.4551 | 24.07, 2.1 | 351.0370, 0.9413 | 351.5961, 0.9430 | |
Lean body mass | 43 | -0.0001, 0.1773 | 6.564, 3.4 | 36.5767, 0.6674 | 38.4609, 0.6271 | |
Trunk fat mass | 383 | 0.0000, 0.0709 | 24.239, 2.0 | 363.6304, 0.7307 | 366.9096, 0.7016 | |