Table 3 Causal association between obesity and head and neck cancer risk

BMI

MR Egger

0.987 (0.974-1.000)

0.018

0.993 (0.985–1.001)

0.051

0.998 (0.989–1.006)

0.31

0.990 (0.978–1.002)

0.051

Weighted median

0.984 (0.975–0.993)

0.0009

0.992 (0.987–0.997)

0.0033

0.998 (0.992–1.005)

0.5625

0.991 (0.982–0.999)

0.0325

Inverse variance weighted

0.990 (0.984–0.996)

0.0005

0.997 (0.993-1.000)

0.0568

0.996 (0.992–0.999)

0.0287

0.993 (0.988–0.998)

0.0037

Weighted mode

0.985 (0.973–0.997)

0.0176

0.991 (0.983–0.998)

0.0154

0.997 (0.990–1.005)

0.4603

0.988 (0.978–0.999)

0.0302

MR-PRESSO

0.990 (0.984–0.995)

0.0004

0.997 (0.994-1.000)

0.0347

0.996 (0.992–0.999)

0.0228

0.993 (0.988–0.997)

0.003

BMI adjust for smoking

MR Egger

0.980 (0.962–0.999)

0.016

0.991 (0.981–1.001)

0.051

0.998 (0.985–1.011)

0.381

0.988 (0.972–1.004)

0.071

Weighted median

0.983 (0.969–0.998)

0.0215

0.992 (0.984-1.000)

0.0531

0.998 (0.988–1.007)

0.6113

0.989 (0.977–1.001)

0.0804

Inverse variance weighted

0.988 (0.978–0.999)

0.0314

0.997 (0.991–1.003)

0.2826

0.997 (0.991–1.004)

0.4005

0.990 (0.981-1.000)

0.0525

Weighted mode

0.981 (0.967–0.995)

0.0158

0.991 (0.982-1.000)

0.0556

0.998 (0.988–1.008)

0.6851

0.988 (0.974–1.001)

0.0889

MR-PRESSO

0.988 (0.978–0.999)

0.0445

0.997 (0.991–1.003)

0.2961

0.997 (0.991–1.003)

0.3464

0.990 (0.981-1.000)

0.0675

WHR

MR Egger

0.997 (0.990–1.005)

0.253

1.000 (0.996–1.004)

0.487

1.000 (0.995–1.005)

0.444

0.999 (0.992–1.006)

0.382

Weighted median

0.998 (0.995–1.001)

0.1739

0.999 (0.998–1.001)

0.4755

0.999 (0.997–1.001)

0.5512

0.997 (0.994-1.000)

0.0265

Inverse variance weighted

0.998 (0.996-1.000)

0.0337

0.999 (0.998-1.000)

0.0973

1.000 (0.999–1.001)

0.9132

0.998 (0.996-1.000)

0.081

Weighted mode

0.996 (0.991–1.002)

0.1841

1.001 (0.997–1.005)

0.662

1.000 (0.996–1.003)

0.7962

0.996 (0.992–1.001)

0.1182

MR-PRESSO

0.998 (0.996-1.000)

0.0313

0.999 (0.998-1.000)

0.1085

1.000 (0.999–1.001)

0.8973

0.998 (0.997-1.000)

0.0804

WHR adjust for BMI

MR Egger

0.997 (0.992–1.002)

0.107

0.999 (0.996–1.002)

0.246

0.998 (0.995–1.002)

0.149

0.997 (0.992–1.002)

0.105

Weighted median

0.999 (0.996–1.001)

0.2271

0.999 (0.998–1.001)

0.3317

0.999 (0.998–1.001)

0.3862

0.998 (0.996-1.000)

0.1031

Inverse variance weighted

0.999 (0.997–1.001)

0.2527

1.000 (0.999–1.001)

0.8027

1.000 (0.999–1.001)

0.5291

0.999 (0.998–1.001)

0.4382

Weighted mode

0.997 (0.993–1.001)

0.2068

0.999 (0.997–1.001)

0.4361

0.999 (0.996–1.002)

0.4694

0.997 (0.994–1.001)

0.1596

MR-PRESSO

0.999 (0.997–1.001)

0.2436

1.000 (0.999–1.001)

0.7749

1.000 (0.999–1.001)

0.5324

0.999 (0.998–1.001)

0.4428

WHR adjust for BMI in non-smoker

MR Egger

0.993 (0.973–1.014)

0.244

0.993 (0.981–1.006)

0.144

0.997 (0.984–1.011)

0.347

0.993 (0.976–1.011)

0.205

Weighted median

0.996 (0.991–1.002)

0.2213

0.998 (0.994–1.001)

0.2221

0.999 (0.995–1.003)

0.705

0.997 (0.991–1.002)

0.2196

Inverse variance weighted

0.997 (0.992–1.002)

0.2011

0.998 (0.996–1.001)

0.2326

0.999 (0.996–1.002)

0.3671

0.997 (0.993–1.001)

0.1689

Weighted mode

0.996 (0.988–1.004)

0.3708

0.996 (0.991–1.002)

0.2556

0.999 (0.993–1.004)

0.6512

0.997 (0.990–1.004)

0.3946

MR-PRESSO

0.997 (0.995-1.000)

0.057

0.998 (0.996–1.001)

0.2754

0.999 (0.996–1.001)

0.3431

0.997 (0.994-1.000)

0.1185

WHR adjust for BMI and smoking

MR Egger

0.997 (0.986–1.009)

0.301

0.997 (0.991–1.004)

0.219

0.997 (0.990–1.005)

0.225

0.996 (0.986–1.006)

0.224

Weighted median

0.998 (0.995–1.001)

0.1999

1.000 (0.998–1.001)

0.6475

1.000 (0.998–1.002)

0.9734

0.998 (0.995–1.001)

0.1753

Inverse variance weighted

0.999 (0.997–1.001)

0.4494

1.000 (0.998–1.001)

0.6971

1.000 (0.998–1.001)

0.6187

0.999 (0.997–1.001)

0.38

Weighted mode

0.998 (0.992–1.003)

0.3614

1.000 (0.997–1.002)

0.7734

1.000 (0.996–1.004)

0.9631

0.997 (0.993–1.002)

0.2348

MR-PRESSO

0.999 (0.997–1.001)

0.4511

1.000 (0.998–1.001)

0.6995

1.000 (0.998–1.001)

0.6248

0.999 (0.997–1.001)

0.3718

Whole body fat mass

MR Egger

0.998 (0.996-1.000)

0.052

1.000 (0.998–1.001)

0.256

0.999 (0.998–1.001)

0.127

0.999 (0.997-1.000)

0.055

Weighted median

0.999 (0.998-1.000)

0.1006

0.999 (0.999-1.000)

0.1419

1.000 (0.999–1.001)

0.7185

0.999 (0.998-1.000)

0.1657

Inverse variance weighted

1.000 (0.999–1.001)

0.4998

1.000 (0.999-1.000)

0.2653

1.000 (1.000-1.001)

0.846

1.000 (0.999-1.000)

0.2323

Weighted mode

0.998 (0.995–1.001)

0.1274

0.998 (0.996-1.000)

0.0304

1.000 (0.998–1.001)

0.7225

0.998 (0.995–1.001)

0.1276

MR-PRESSO

1.000 (0.999–1.001)

0.4955

1.000 (0.999-1.000)

0.2397

1.000 (1.000-1.001)

0.8377

1.000 (0.999-1.000)

0.2062

Lean body mass

MR Egger

0.999 (0.997–1.002)

0.331

1.000 (0.998–1.001)

0.328

1.000 (0.999–1.002)

0.331

1.000 (0.998–1.002)

0.462

Weighted median

1.000 (0.999–1.001)

0.9473

1.000 (0.999-1.000)

0.764

1.000 (1.000-1.001)

0.4834

1.000 (0.999–1.001)

0.8908

Inverse variance weighted

1.000 (0.999–1.001)

0.8881

1.000 (1.000–1.000)

0.6678

1.000 (1.000-1.001)

0.5034

1.000 (1.000-1.001)

0.9009

Weighted mode

1.000 (0.998–1.002)

0.9713

1.000 (0.999–1.001)

0.8471

1.000 (0.999–1.001)

0.7963

1.000 (0.998–1.002)

0.8159

MR-PRESSO

1.000 (0.999-1.000)

0.8723

1.000 (1.000–1.000)

0.6143

1.000 (1.000-1.001)

0.4843

1.000 (1.000-1.001)

0.8971

Trunk fat mass

MR Egger

0.999 (0.996–1.001)

0.11

1.000 (0.998–1.001)

0.245

0.999 (0.998–1.001)

0.178

0.999 (0.997-1.000)

0.061

Weighted median

0.999 (0.998–1.001)

0.2767

1.000 (0.999-1.000)

0.4351

1.000 (0.999–1.001)

0.4721

0.999 (0.998-1.000)

0.1263

Inverse variance weighted

1.000 (0.999–1.001)

0.5994

1.000 (1.000–1.000)

0.8589

1.000 (1.000-1.001)

0.6184

1.000 (0.999–1.001)

0.7999

Weighted mode

0.998 (0.995–1.001)

0.2085

0.999 (0.997-1.000)

0.1413

0.999 (0.998–1.001)

0.5802

0.998 (0.995-1.000)

0.1097

MR-PRESSO

1.000 (0.999–1.001)

0.5997

1.000 (1.000–1.000)

0.8535

1.000 (1.000-1.001)

0.6108

1.000 (0.999–1.001)

0.796