Association of integrin-β2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients

Table 1 Demographic, biochemical, and clinicopathological data of RA and OA patients

Parameter	Healthy controls (n = 60)	RA (n = 70)	OA (n = 70)	P-value
Age (years)	55.11 ± 4.70	53.19 ± 5.2	56.40^b ± 5.49	0.001
Sex, n (%)
Female Male	54 (90) 6 (10)	68 (97.2) 2 (2.8)	67 (95.7) 3 (4.3)	0.47
CRP, mg/L	6 (3.95-7)	34^a (22.50–55)	5^b (4-7.5)	< 0.0001
ESR (mm/h)	13.08 ± 0.62	44.58^a ± 3.39	12.95^b ± 0.75	< 0.0001
RF	5.722 ± 0.25	41.23^a ± 5.14	5.506^b ± 0.23	< 0.0001
ALT, U/L	22.17 ± 1.26	22.28 ± 0.89	22.36 ± 1.097	0.608
AST, U/L	22.17 ± 1.35	22.54 ± 1.08	22.58 ± 1.20	0.11
TLC (x 1000/mm³)	6.26 ± 0.23	8.04^a ± 0.55	6.40^b ± 0.23	< 0.0001
DAS28 Mild-Moderate, n (%) Severe, n (%)	-	5.011 ± 0.98 32 (45.72) 38 (54.28)	-	-
KL score ≤ 2, n (%) > 2, n (%)	-	-	2.77 ± 0.8 32 (45.72) 38 (54.28)	-

Values are expressed as mean ± SD or number (percentage). CRP levels were not normally distributed and are expressed as median (interquartile range). P-values of one-way ANOVA followed by Tukey post-hoc test, Kruskal-Wallis test followed by Dunn’s multiple comparison, or chi square tests are presented. Multiplicity adjusted P-values following Tukey multiple comparison test was computed using GraphPad Prism 6.0. ^a significant difference from control group; ^b significant difference from RA group. Bold indicates statistical significance, P < 0.05. ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; DAS28, disease activity score 28; ESR, erythrocyte sedimentation rate; KL, Kellgren–Lawrence; OA, osteoarthritis; RA, rheumatoid arthritis; RF, rheumatoid factor; TLC, total leukocyte count.

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