Fig. 5

Correlation and DE analysis between targeted mRNAs and clinical parameters related to T2DM, using public BxD mouse database: GeneNetwork. A Spearman’s correlation analysis between hepatic IRS2 expression (x-axis) in BxD high-fat diet (HFD) mice and Insulin (y-axis) during OGTT and (B) the comparison between the highest 25% mice (HFD) of IRS2 gene expression with the bottom 25% mice (HFD) of the gene expression. C Spearman’s correlation analysis between hepatic IRS expression in BxD chow diet (CD) mice and insulin response (IR) during OGTT and (D) the comparison between the top 25% mice (CD) of IRS2 gene expression with the bottom 25% mice (CD) of the gene expression. E Spearman’s correlation analysis between hepatic IGF1R expression level in BxD HFD mice and glycemia level during OGTT and (F) the comparison between the top 25% mice (HFD) of IGF1R gene expression with the bottom 25% mice of the gene. G Spearman’s correlation analysis between hepatic PIK3CD expression level in BxD HFD mice and IR during OGTT and (H) the comparison between the top 25% mice (HFD) of PIK3CD gene expression with the bottom 25% mice (HFD) of the gene