Table 2 Causal associations between genetically determined IBD level and IgAN

Exposure-

outcome

Causal estimate

Method

SNP

OR

95% CI

P value

IBD

Inverse variance weighted*

67

1.78

1.45–2.19

< 0.001

Weighted median

67

1.82

1.33–2.49

< 0.001

Weighted mode

67

1.91

1.16–3.14

0.01

Simple mode

67

1.66

0.86–3.20

0.14

MR Egger

67

1.60

0.88–2.93

0.13

Test for Heterogeneity: P = 0.53 (MR-Egger) and P = 0.56 (IVW)

Test for Horizontal pleiotropy: MR-Egger intercept = 0.0112, se = 0.031, P = 0.72

MR-PRESSO global test: P = 0.67