Table 3 Effect of candidate variants on susceptibility to GC
From: Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer
SNP-ID | Model | Genotype | Control (%) | Case (%) | OR (95%CI) | p |
|---|---|---|---|---|---|---|
rs10036575 | Co-dominant | TT | 138 (27.3) | 164 (32.3) | 1 | 0.035 |
CT | 239 (47.2) | 238 (46.9) | 0.84 (0.63–1.12) | |||
CC | 129 (25.5) | 106 (20.8) | 0.69 (0.49–0.97) | |||
Dominant | TT | 138 (27.3) | 164 (32.3) | 1 | 0.084 | |
CC-CT | 368 (72.7) | 344 (67.7) | 0.79 (0.60–1.03) | |||
Recessive | CT-TT | 377 (82.1) | 402 (79.1) | 1 | 0.081 | |
CC | 127 (17.9) | 106 (20.9) | 0.77 (0.57–1.03) | |||
Log-additive | --- | --- | --- | 0.83 (0.70–0.98) | 0.034 | |
rs10074991 | Co-dominant | GG | 136 (26.9) | 164 (32.3) | 1 | 0.028 |
AG | 241 (47.6) | 239 (47.0) | 0.83 (0.62–1.10) | |||
AA | 129 (25.5) | 106 (20.9) | 0.68 (0.48–0.96) | |||
Dominant | GG | 136 (26.9) | 164 (32.3) | 1 | 0.065 | |
AA-AG | 370 (73.1) | 344 (67.7) | 0.77 (0.60–1.02) | |||
Recessive | AG-GG | 377 (74.5) | 402 (79.1) | 1 | 0.078 | |
AA | 129 (25.5) | 106(20.9) | 0.77 (0.58–1.03) | |||
Log-additive | --- | --- | --- | 0.83 (0.70–0.98) | 0.028 | |
rs13361707 | Co-dominant | CC | 136 (26.9) | 164 (32.2) | 1 | 0.036 |
TC | 242 (47.8) | 238 (46.8) | 0.82 (0.61–1.09) | |||
TT | 128 (25.3) | 107 (21.0) | 0.69 (0.49–0.98) | |||
Dominant | CC | 136 (26.9) | 164 (32.2) | 1 | 0.065 | |
TT-TC | 370 (73.1) | 345 (67.8) | 0.77 (0.59–1.02) | |||
Recessive | TC-CC | 378 (74.7) | 402 (79.0) | 1 | 0.107 | |
TT | 128 (25.3) | 107 (21.0) | 0.78 (0.58–1.05) | |||
Log-additive | --- | --- | --- | 0.83 (0.70–0.99) | 0.034 |