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Table 4 Association between selected polymorphisms and GC risk according to stratification by smoking

From: Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer

SNP-ID

Model

Genotype

Smoking

Non-Smoking

OR (95% CI)

p

OR (95% CI)

p

rs10036575

Co-dominant

T/T

1

0.507

1

0.837

 C/T

0.86 (0.54–1.35)

1.05 (0.63–1.79)

C/C

0.74 (0.43–1.26)

---

Dominant

T/T

1

0.347

1

0.556

 C/C-C/T

0.81 (0.53–1.25)

0.87 (0.54–1.40)

Recessive

C/T-T/T

1

0.360

1

0.045

 C/C

0.81 (0.52–1.27)

0.59 (0.35–0.99)

Log-additive

---

0.86 (0.66–1.12)

0.259

0.79 (0.59–1.07)

0.131

rs10074991

Co-dominant

G/G

1

0.361

1

0.712

 A/G

0.81 (0.51–1.28)

1.11 (0.65–1.87)

A/A

0.72 (0.43–1.24)

---

Dominant

G/G

1

0.259

1

0.609

 A/A-A/G

0.78 (0.50–1.20)

0.88 (0.55–1.43)

Recessive

A/G-G/G

1

0.424

1

0.029

 A/A

0.83 (0.53–1.31)

0.56 (0.34–0.94)

Log-additive

---

0.85 (0.65–1.11)

0.237

0.79 (0.58–1.06)

0.119

rs13361707

Co-dominant

C/C

1

0.317

1

0.677

T/C

0.79 (0.42–1.23)

1.12 (0.66–1.90)

T/T

0.72 (0.50–1.25)

---

Dominant

C/C

1

0.226

1

0.666

T/T-T/C

0.77 (0.50–1.18)

0.90 (0.56–1.45)

Recessive

T/C-C/C

1

0.424

1

0.037

T/T

0.83 (0.53–1.31)

0.58 (0.35–0.97)

Log-additive

---

0.85 (0.65–1.10)

0.218

0.80 (0.59–1.08)

0.145

  1. SNP: single nucleotide polymorphism; OR: odds ratio; 95% CI: 95% confidence interval: BMI: body mass index
  2. p values were calculated by logistic regression analysis with adjustments for adenocarcinoma, smoking, and BMI.
  3. Bold font and p < 0.05 respects the data is statistically significant