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Table 5 Association between selected polymorphisms and the risk of GC according to the adenocarcinoma and other

From: Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer

SNP-ID

Model

Genotype

Adenocarcinoma

OR (95% CI)

p

rs10036575

Co-dominant

T/T

1

0.046

 C/T

0.91 (0.66–1.27)

C/C

0.67(0.45–0.99)

Dominant

T/T

1

0.226

 C/C-C/T

0.83 (0.61–1.13)

Recessive

C/T-T/T

1

0.045

 C/C

0.70 (0.50-1.00)

Log-additive

---

0.82 (0.68-1.00)

0.053

rs10074991

Co-dominant

G/G

1

0.034

 A/G

0.88 (0.63–1.22)

A/A

0.65 (0.44–0.97)

Dominant

G/G

1

0.153

 A/A-A/G

0.80 (0.59–1.09)

Recessive

A/G-G/G

1

0.045

 A/A

0.70 (0.50-1.00)

Log-additive

---

0.81 (0.67–0.99)

0.038

rs13361707

Co-dominant

C/C

1

0.511

T/C

0.88 (0.64–1.23)

T/T

0.67 (0.45-1.00)

Dominant

C/C

1

0.182

T/T-T/C

0.81 (0.59–1.10)

Recessive

T/C-C/C

1

0.068

T/T

0.73 (0.52–1.02)

Log-additive

---

0.82 (0.68-1.00)

0.055

  1. SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustments for adenocarcinoma, smoking and BMI.
  3. Bold font and p < 0.05 respects the data is statistically significant