Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer

BMC Medical Genomics

Table 6 SNP–SNP interaction models of candidate SNPs analyzed by MDR method

Model	Training Bal. Acc.	Testing Bal. Acc.	OR(95%CI)	p value	CV Consistency
rs10036575	0.527	0.504	1.28 (0.98–1.67)	0.075	10/10
rs9292777, rs10036575	0.540	0.483	1.34 (1.05–1.72)	0.020	4/10
rs9292777, rs12186979, rs10036575	0.555	0.480	1.53 (1.19–1.96)	0.001	6/10
rs6880778, rs7725052, rs12186979, rs10036575	0.570	0.454	1.69 (1.32–2.18)	< 0.001	5/10
rs11742570, rs9292777, rs7725052, rs12186979, rs10036575	0.573	0.456	1.74 (1.35–2.24)	< 0.001	5/10
rs4613763, rs11742570, rs9292777, rs7725052, rs12186979, rs10036575	0.574	0.470	1.77 (1.38–2.28)	< 0.001	7/10
rs4613763, rs6880778, rs11742570, rs9292777, rs7725052, rs12186979, rs10036575	0.574	0.470	1.78 (1.38–2.28)	< 0.001	10/10

MDR: multi-factor dimensionality reduction; Bal. Acc.: balanced accuracy; CVC: cross-validation consistency; OR: odds ratio; 95% CI: 95% confidence interval
Bold values indicate that the value is statistically significant
p values were calculated using χ² tests
Bold font and p < 0.05: indicates statistical significance

ISSN: 1755-8794