Table 2 Six Hub Genes

IFIT1

Upregulation

Interferon induced protein with tetratricopeptide repeats 1

Hepatitis C

response to virus, defense response to virus, defense response to symbiont, regulation of response to biotic stimulus, response to type I interferon, cellular response to type I interferon, negative regulation of protein binding, etc.

IFIT2

Upregulation

Interferon induced protein with tetratricopeptide repeats 2

/

response to virus, defense response to virus, negative regulation of protein binding, regulation of binding

IFIT3

Upregulation

Interferon induced protein with tetratricopeptide repeats 3

/

response to virus, response to interferon-alpha, defense response to virus, response to interferon-alpha, defense response to symbiont

ISG15

Upregulation

ISG15 ubiquitin like modifier

Epstein-Barr virus infection, RIG-I-like receptor signaling pathway, Human papillomavirus infection

regulation of interferon-gamma production, interferon-gamma production, response to virus, negative regulation of immune system process, regulation of hemopoiesis, defense response to symbiont, regulation of response to biotic stimulus, regulation of innate immune response, etc.

MX1

Upregulation

MX dynamin like GTPase 1

Measles, Influenza A, Human papillomavirus infection, Hepatitis C

response to virus, defense response to virus, defense response to symbiont, negative regulation of viral process, viral process, regulation of viral process, regulation of viral life cycle, viral genome replication, etc.

RSAD2

Upregulation

Radical S-adenosyl methionine domain containing 2

Influenza A, Hepatitis C

type 2 immune response, response to virus, positive regulation of cytokine production, mononuclear cell differentiation, defense response to symbiont, T cell differentiation, negative regulation of viral genome replication, regulation of immune effector process, CD4-positive alpha-beta T cell differentiation, regulation of adaptive immune response, etc.