Table 4 The up-regulated TFs based on DEGs related to the six hub genes
Transcription Factor | Genes targeted by Transcription Factor | Gene count (≥ 3) | ||
|---|---|---|---|---|
NFE2 | RSAD2, MX1, ISG15, IFIT1, IFIT3, IFIT2 | 6 | ||
ASCL2 | RSAD2, MX1, ISG15, IFIT1, IFIT3, IFIT2 | 6 | ||
EGR2 | RSAD2, ISG15, IFIT1, IFIT3, IFIT2 | 5 | ||
MAFB | RSAD2, ISG15, IFIT1, IFIT3, IFIT2 | 5 | ||
NR1H3 | RSAD2, ISG15, IFIT1, IFIT3, IFIT2 | 5 | ||
ZNF467 | RSAD2, ISG15, IFIT1, IFIT3, IFIT2 | 5 | ||
TFEC | RSAD2, MX1, IFIT1, IFIT3, IFIT2 | 5 | ||
KLF4 | RSAD2, ISG15, IFIT3, IFIT2 | 4 | ||
POU2F2 | MX1, ISG15, IFIT3, IFIT2 | 4 | ||
MYC | RSAD2, MX1, ISG15, IFIT1 | 4 | ||
HHEX | RSAD2, IFIT1, IFIT3, IFIT2 | 4 | ||
BCL6 | IFIT1, IFIT3, IFIT2 | 3 | ||
CUX1 | MX1, ISG15, IFIT2 | 3 | ||
FLI1 | ISG15, IFIT3, IFIT2 | 3 | ||
TAL1 | RSAD2, ISG15, IFIT1 | 3 | ||
EGR1 | ISG15, IFIT3, IFIT2 | 3 | ||
ZNF404 | IFIT1, IFIT3, IFIT2 | 3 | ||
ZNF705A | RSAD2, IFIT3, IFIT2 | 3 | ||
ZFP92 | RSAD2, IFIT1, IFIT3 | 3 | ||
ZNF177 | ISG15, IFIT1, IFIT3 | 3 | ||
ZNF488 | IFIT1, IFIT3, IFIT2 | 3 |