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Table 2 Patient demographics

From: Diagnostic yield of targeted next-generation sequencing for pediatric hereditary hemolytic anemia

Characteristics

LP/P

VOUS/none

Total

P-value

Age (yrs)

    

0.084

 

N

18

11

29

 
 

Median

5

14

8

 
 

IQR

6.75

18

11.5

 

Gender, n (%)

   

0.125

 

Female

9 (50.0)

9 (81.8)

18 (62.1)

 
 

Male

9 (50.0)

2 (18.2)

11 (37.9)

 

Hb (g/dL)

    

0.794

 

N

18

11

29

 
 

Mean (SD)

10.03 (1.99)

10.25 (2.28)

10.11 (2.11)

 

Reticulocyte (%)

   

0.146

 

N

17

8

25

 
 

Mean (SD)

9.35 (4.54)

6.07 (6.16)

8.57 (5.15)

 

Reticulocyte count (×103/µL)

   

0.117

 

N

17

8

25

 
 

Mean (SD)

323.44 (158.19)

203.35 (200.29)

291.94 (178.26)

 

RDW (%)

    

0.233

 

N

18

11

29

 
 

Mean (SD)

18.77 (3.30)

17.16 (3.67)

18.16 (3.50)

 

Poikilocytosis

   

0.044

 

-

4

7

11

 
 

1+

8

1

9

 
 

2+

1

2

3

 
 

3+

1

0

1

 
 

4+

1

0

1

 

LDH (IU/L)

   

0.872

 

N

18

8

26

 
 

Mean (SD)

348.72 (165.63)

337.75 (154.53)

345.35 (135.33)

 

Total bilirubin (mg/dL)*

  

0.106

 

N

17

9

26

 
 

Mean (SD)

2.69 (2.15)

1.33 (1.48)

2.22 (2.03)

 
  1. *Two values below the analytical measurement range (< 0.15) were excluded
  2. Abbreviations: LP, likely pathogenic; P, pathogenic; VOUS, variant of unknown significance; SD, standard deviation; Hb, hemoglobin; RDW, red blood cell distribution width; LDH, lactate dehydrogenase