Table 2 MR results for the effect of smoking and alcohol drink behaviors on Dupuytren’s disease
From: Smoking, alcohol consumption and risk of Dupuytren’s disease: a Mendelian randomization study
Behaviour | SNPs, N | Method | OR | 95%CI | P value | P for pleiotropy | P for Cochran’s Q | P for global test |
|---|---|---|---|---|---|---|---|---|
Drinks per week | 36 | IVW | 2.948 | (1.746,4.975) | 5.16E-05 | 0.864 | 0.428 | 0.429 |
MR-Egger | 3.272 | (0.886,12.077) | 8.41E-02 | |||||
RAPS | 2.962 | (1.722,5.097) | 8.73E-05 | |||||
WME | 2.847 | (1.289,6.289) | 1.03E-02 | |||||
SME | 3.007 | (1.347,6.709) | 6.86E-03 | |||||
MR-PRESSO | - | - | - | |||||
Cigarettes per day | 21 | IVW | 1.051 | (0.850,1.299) | 6.45E-01 | 0.907 | 0.675 | 0.685 |
MR-Egger | 1.080 | (0.650,1.793) | 7.68E-01 | |||||
RAPS | 1.023 | (0.821,1.276) | 8.34E-01 | |||||
WME | 0.936 | (0.686,1.277) | 6.79E-01 | |||||
SME | 0.885 | (0.635,1.231) | 4.69E-01 | |||||
MR-PRESSO | - | - | - | |||||
Smoking initiation | 80 | IVW | 1.162 | (0.917,1.472) | 2.12E-01 | 0.261 | 0.016 | 0.017 |
MR-Egger | 2.267 | (0.695,7.399) | 1.78E-01 | |||||
RAPS | 1.112 | (0.873,1.416) | 3.87E-01 | |||||
WME | 1.190 | (0.870,1.628) | 2.75E-01 | |||||
SME | 1.089 | (0.806,1.471) | 5.76E-01 | |||||
MR-PRESSO | - | - | - | |||||
Age of initiation | 6 | IVW | 0.472 | (0.131,1.702) | 2.51E-01 | 0.492 | 0.117 | 0.147 |
MR-Egger | 2.027 | (0.036,111.834) | 7.47E-01 | |||||
RAPS | 0.354 | (0.126,0.995) | 4.91E-01 | |||||
WME | 0.401 | (0.101,1.593) | 1.94E-01 | |||||
SME | 0.275 | (0.073,1.025) | 5.40E-02 | |||||
MR-PRESSO | - | - | - | |||||
Smoking cessation | 6 | IVW | 0.719 | (0.462,1.119) | 1.44E-01 | 0.739 | 0.552 | 0.630 |
MR-Egger | 0.962 | (0.183,5.058) | 9.66E-01 | |||||
RAPS | 0.715 | (0.451,1.134) | 1.54E-01 | |||||
WME | 0.749 | (0.434,1.291) | 2.98E-01 | |||||
SME | 0.766 | (0.458,1.280) | 3.09E-01 | |||||
MR-PRESSO | - | - | - |