Fig. 3
Construction of weighted co-expression network and mining hub genes. A Sample clustering. To identify and remove outliers. B Soft threshold selection process. 7.0 was selected as the optimal soft threshold with an R2=0.85. C, D Cluster dendrogram. Divided the miRNAs into different modules according to dynamic tree cutting algorithm; Each color represents one specific co-expression module; After merging, a total of six modules were generated. E Heatmap of the correlation between clinical traits (survival and tumor) and modules; Red represents positive correlation, green represents negative correlation, and the color shade represents the degree of correlation. F-G Hub miRNAs selection. The upper right quadrant is hub miRNAs; 175 miRNAs related to tumor and 169 miRNAs related to survival in turquoise module; The criteria were |MM|>0.8 and |GS|>0.2. miRNAs, microRNAs