Fig. 5

Identification of characteristic miRNAs for GBC based on machine learning. A, B LASSO algorithm. Using the LASSO algorithm, we identified six characteristic miRNAs. C ROC curve of LASSO model. To assess the diagnostic sensitivity and specificity of the LASSO model. D SVM-RFE algorithm. We identified eight characteristic miRNAs by the SVM-RFE algorithm. E Venn diagram of LASSO and SVM-RFE. To display the overlapped characteristic miRNA: hsa-miR-4770. F ROC curve of hsa-miR-4770. To investigate the diagnostic ability of hsa-miR-4770. miRNAs, microRNAs; GBC, gallbladder carcinoma; DE-miRNAs, differentially expressed miRNAs; LASSO, least absolute shrinkage and selection operator; SVM-RFE, support vector machine-recursive feature elimination; ROC, receiver operating characteristic