Fig. 9

Investigation of hsa-miR-4770-related regulatory network. A The construction of ceRNA subnetwork based on top 10 key genes and hsa-miR-4770. The square represents hsa-miR-4770; The triangular diamond represents lncRNA; The dot represents the mRNAs. The hexagon represents the circRNA; Blue and red represent downregulation and downregulation. B The miRNA-transcription factor (TFs) network. The hexagons represent TFs, and the ellipse represents hsa-miR-4770. C-E The expression levels of 10 key genes and hsa-miR-4770 between GBC and NBG groups. C The hsa-miR-4770 was down-regulated in GBC; (D) CD44 and KRT19 were up-regulated in GBC; (E) RB1, BRCA1, PTGS2, CASP8, CDK1, CHEK2, MXRA5, and PVT1 were up-regulated in GBC. F The expression of hsa-miR-4770 at transcriptional level. The hsa-miR-4770 was reduced in GBC samples (P=0.0147). ceRNA, competing endogenous RNA; lncRNA GBC, long noncoding RNA; circRNA, circularRNA; TFs, transcription factors; gallbladder carcinoma; NGB, normal gallbladder