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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Novel mutations of the X-linked genes associated with early-onset high myopia in five Chinese families

Fig. 1

Sequence analysis and clinical examination of the family 1: (A) Pedigree of the family 1:The filled black symbol represents the affected member, a central dot denotes carriers, and the arrow denotes the proband. (B) The fundus of both eyes: macular OCT of both eyes suggested thinning of the macular fovea and autofluorescence in both eyes suggested a slightly wider range of hypofluorescence in the macula. (C) ERG showed significantly decline in cone function and normal rod function in both eyes. (D) Sequence chromatograms of identified mutations. (E) The homology of amino acid sequences between human OPN1LW and other species. The amino acid at position 266 is highly conserved among species, and the mutated residue 266 is boxed and indicated

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BMC Medical Genomics

ISSN: 1755-8794

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