Table 1 Positive IVW-MR results of causal links between gut microbiome and AILD subtypes risk

AIH

 Class_Clostridia

12

0.58 (0.35 to 0.97)

0.039

 Family_Victivallaceae

12

1.42 (1.11 to 1.81)

0.005

 Genus_Anaerostipes

13

0.35 (0.17 to 0.74)

0.006

 Genus_Clostridium innocuum group

9

0.67 (0.49 to 0.93)

0.017

 Genus_Holdemania

15

0.66 (0.46 to 0.95)

0.025

 Genus_Ruminiclostridium9

9

0.39 (0.20 to 0.76)

0.006

 Genus_Ruminococcaceae NK4A214 group

13

1.64 (1.03 to 2.64)

0.039

PBC

 Class_Coriobacteriia

3

2.18 (1.30 to 3.66)

0.003

 Class_Deltaproteobacteria

4

0.52 (0.36 to 0.74)

 < 0.001

 Order_Coriobacteriales

3

2.18 (1.30 to 3.66)

0.003

 Family_Coriobacteriaceae

3

2.18 (1.30 to 3.66)

0.003

 Family_Desulfovibrionaceae

3

0.53 (0.34 to 0.81)

0.003

 Genus_Ruminiclostridium5

4

1.47 (1.03 to 2.09)

0.032

PSC

 Phylum_Tenericutes

5

1.66 (1.06 to 2.61)

0.027

 Class_Mollicutes

5

1.66 (1.06 to 2.61)

0.027

 Order_Actinomycetales

3

0.59 (0.36 to 0.98)

0.042

 Family_Actinomycetaceae

3

0.60 (0.36 to 0.98)

0.042

 Family_Clostridiales vadin BB60 group

10

0.73 (0.54 to 0.98)

0.035

 Family_Oxalobacteraceae

5

1.44 (1.08 to 1.91)

0.014

 Genus_Actinomyces

4

0.62 (0.42 to 0.90)

0.012

 Genus_Alloprevotella

3

0.68 (0.50 to 0.94)

0.018