Causal effects of gut microbiome on autoimmune liver disease: a two-sample Mendelian randomization study

BMC Medical Genomics

Table 2 The causal effects of genus_Clostridium_innocuum_group and genus_Actinomyces on AILD subtypes

Gut microbiome	Methods	OR (95% CI)	P-value	Q statistic	PQ	Egger intercept	Pintercept
AIH
Genus_Clostridium_innocuum_group	MR Egger	0.63(0.18–2.26)	0.49	5.02	0.66	0.11	0.32
	Weighted median	0.65(0.32–1.33)	0.24
	Simple mode	0.59(0.22–1.58)	0.31
	Weighted mode	0.66(0.29–1.48)	0.34
	Inverse variance weighted	0.58(0.35–0.97)	0.04	8.81	0.64	-0.01	0.9
PSC
Genus_Actinomyces	MR Egger	0.79(0.17–3.59)	0.79	0.99	0.61	-0.03	0.77
	Weighted median	0.66(0.42–1.03)	0.07
	Simple mode	0.70(0.37–1.31)	0.34
	Weighted mode	0.71(0.39–1.30)	0.35
	Inverse variance weighted	0.62(0.42–0.90)	0.01	1.1	0.78	-0.03	0.77

OR odds ratio, CI confidence interval, PQ p-value of Q test. Cochran’s Q tests heterogeneity; MR-Egger detects directional pleiotropy

ISSN: 1755-8794