Assessment of causal effects of physical activity on the risk of osteoarthritis: a two-sample Mendelian randomization study

Table 1 The causal effect of LST on overall OA, hip OA and knee OA

Exposure	Outcome	SNPs	MR methods	OR	95% CI	Q_pval	Intercept_pval
LST	overall OA	108	IVW	1.309	(1.198, 1.430)	8.944E-07	0.849
			MR- Egger	1.261	(0.852, 1.867)	6.663E-07
			WM	1.292	(1.167, 1.430)
	hip OA	108	IVW	1.132	(1.009, 1.269)	0.025	0.286
			MR- Egger	1.482	(0.894, 2.456)	0.027
			WM	1.146	(0.985, 1.332)
	knee OA	108	IVW	1.435	(1.286, 1.602)	9.241E-08	0..386
			MR- Egger	1.163	(0.715, 1.891)	9.412E-08
			WM	1.476	(1.306, 1.667)

The Q_pval was executed by the MR-Egger and IVW methods to detect heterogeneity. The intercept p-value was derived from the pleiotropy test of MR-Egger regression
Abbreviations: LST leisure screen time, OA osteoarthritis, SNPs single-nucleotide polymorphisms, MR Mendelian randomization, CI confidence interval, OR odds ratio, IVW inverse variance-weighted, WM weighted median

ISSN: 1755-8794