Assessment of causal effects of physical activity on the risk of osteoarthritis: a two-sample Mendelian randomization study

Table 2 The causal effect of MVPA on overall OA, hip OA and knee OA

Exposure	Outcome	SNPs	MR methods	OR	95%CI	Q_pval	Intercept_pval
MVPA	overall OA	15	IVW	0.895	(0.664, 1.205)	8.365E-04	0.854
			MR- Egger	0.748	(0.112, 4.992)	4.890E-04
			WM	0.014	(0.764, 1.345)
	hip OA	15	IVW	1.189	(0.792, 1.786)	0.011	0.510
			MR- Egger	2.837	(0.222, 36.277)	0.009
			WM	1.440	(0.933, 2.223)
	knee OA	15	IVW	0.707	(0.490, 1.021)	6.427E-04	0.538
			MR- Egger	0.338	(0.033, 3.426)	5.368E-04
			WM	0.651	(0.455, 0.932)

The Q_pval was executed by the MR-Egger and IVW methods to detect heterogeneity
The intercept p-value was derived from the pleiotropy test of MR-Egger regression
Abbreviations: MVPA moderate to vigorous intense physical activity during leisure screen time, OA osteoarthritis, SNPs single-nucleotide polymorphisms, MR Mendelian randomization, CI confidence interval, OR odds ratio, IVW inverse variance-weighted, WM weighted median

ISSN: 1755-8794