Table 3 Association of CYP4V2 gene polymorphisms with CHD risk in an overall analysis
SNP_ID | Model | Genotypes | Case | Controls | Adjusted | |
|---|---|---|---|---|---|---|
OR (95% CI) | p | |||||
rs1398007 | Co-dominant | CC | 218 | 240 | 1 | |
CT | 22 | 208 | 1.17(0.90–1.53) | 0.241 | ||
TT | 47 | 39 | 1.32(0.83–2.10) | 0.244 | ||
Dominant | CC | 218 | 240 | 1 | ||
CT + TT | 269 | 247 | 1.20(0.93–1.54) | 0.169 | ||
Recessive | CC + CT | 440 | 448 | 1 | ||
TT | 47 | 39 | 1.22(0.78–1.91) | 0.381 | ||
Log-additive | — | — | — | 1.16(0.95–1.41) | 0.145 | |
rs13146272 | Co-dominant | CC | 177 | 188 | 1 | |
CA | 239 | 225 | 1.13(0.86–1.49) | 0.373 | ||
AA | 70 | 74 | 0.98(0.67–1.45) | 0.924 | ||
Dominant | CC | 177 | 188 | 1 | ||
CA + AA | 309 | 299 | 1.10(0.84–1.42) | 0.494 | ||
Recessive | CC + CA | 416 | 413 | 1 | ||
AA | 70 | 74 | 0.92(0.64–1.31) | 0.626 | ||
Log-additive | — | — | — | 1.02(0.85–1.23) | 0.817 | |
rs3736455 | Co-dominant | TT | 168 | 174 | 1 | |
TG | 254 | 240 | 1.09(0.83–1.44) | 0.532 | ||
GG | 65 | 71 | 0.93(0.62–1.38) | 0.714 | ||
Dominant | TT | 168 | 174 | 1 | ||
TG + GG | 319 | 311 | 1.05(0.81–1.37) | 0.694 | ||
Recessive | TT + TG | 422 | 414 | 1 | ||
GG | 65 | 71 | 0.88(0.61–1.27) | 0.496 | ||
Log-additive | — | — | — | 0.99(0.82–1.20) | 0.942 | |
rs1053094 | Co-dominant | TT | 192 | 209 | 1 | |
TA | 233 | 225 | 1.14(0.87–1.49) | 0.348 | ||
AA | 62 | 52 | 1.31(0.86–2.00) | 0.201 | ||
Dominant | TT | 192 | 209 | 1 | ||
TA + AA | 259 | 277 | 1.17(0.91–1.51) | 0.229 | ||
Recessive | TT + TA | 425 | 434 | 1 | ||
AA | 62 | 52 | 1.23(0.83–1.82) | 0.308 | ||
Log-additive | — | — | — | 1.14(0.95–1.38) | 0.166 | |
rs56413992 | Co-dominant | CC | 288 | 326 | 1 | |
CT | 175 | 144 | 1.40(1.06–1.83) | 0.017 | ||
TT | 24 | 15 | 1.79(0.92–3.48) | 0.088 | ||
Dominant | CC | 288 | 326 | 1 | ||
CT + TT | 199 | 159 | 1.43(1.10–1.87) | 0.007 | ||
Recessive | CC + CT | 463 | 470 | 1 | ||
TT | 24 | 15 | 1.60(0.83–3.09) | 0.164 | ||
Log-additive | — | — | — | 1.37(1.10–1.72) | 0.006 | |