Skip to main content

Table 8 The effect of CYP4V2 gene polymorphisms on whether CHD was complicated by diabetes mellitus (DM) or hypertension (HTN) risk

From: CYP4V2 rs56413992 C > T was associated with the risk of coronary heart disease in the Chinese Han population: a case–control study

SNP_ID

Model

Genotypes

Case

(With DM)

Controls

(Without DM)

OR (95% CI)

p

Case

(With HTN)

Controls

(Without HTN)

OR (95% CI)

p

rs1398007

Co-dominant

CC

62

156

1

 

150

68

1

 

CT

63

159

1.03(0.67–1.57)

0.908

122

100

0.57(0.38–0.84)

0.005

TT

18

29

1.64(0.894–3.21)

0.147

31

16

0.90(0.46–1.78)

0.764

Dominant

CC

62

156

1

 

150

68

1

 

CT + TT

81

188

1.12(0.75–1.67)

0.586

153

116

0.61(0.42–0.90)

0.012

Recessive

CC + CT

125

315

1

 

272

168

1

 

TT

18

29

1.62(0.86–3.05)

0.135

31

16

1.22(0.64–2.33)

0.524

Log-additive

1.19(0.88–1.61)

0.269

0.79(0.59–1.05)

0.102

rs13146272

Co-dominant

CC

59

118

1

 

111

66

1

 

CA

59

180

0.65(0.42–1.01)

0.057

149

90

0.96(0.64–1.46)

0.862

AA

25

45

1.05(0.58–1.90)

0.870

43

21

0.87(0.49–1.57)

0.651

Dominant

CC

59

118

1

 

111

66

1

 

CA + AA

84

225

0.74(0.49–1.11)

0.140

192

117

0.94(0.64–1.40)

0.768

Recessive

CC + CA

118

298

1

 

260

156

1

 

AA

25

45

1.33(0.77–2.28)

0.304

43

27

0.89(0.52–1.52)

0.676

Log-additive

0.93(0.69–1.24)

0.612

0.94(0.71–1.24)

0.670

rs3736455

Co-dominant

TT

56

112

1

 

106

62

1

 

TG

62

192

0.63(0.41–0.97)

0.037

155

99

0.87(0.57–1.31)

0.494

GG

25

40

1.18(0.64–2.16)

0.593

42

23

0.98(0.53–1.81)

0.956

Dominant

TT

56

112

1

 

106

62

1

 

TG + GG

87

232

0.72(0.48–1.10)

0.126

197

122

0.89(0.60–1.32)

0.558

Recessive

TT + TG

118

304

1

 

261

161

1

 

GG

25

40

1.55(0.89–2.68)

0.122

42

23

1.07(0.61–1.87)

0.805

Log-additive

0.96(0.71–1.29)

0.771

0.96(0.72–1.27)

0.768

rs1053094

Co-dominant

TT

69

123

1

 

122

70

1

 

TA

61

172

0.63(0.42–0.96)

0.032

144

89

0.92(0.61–1.38)

0.687

AA

13

49

0.48(0.24–0.94)

0.033

37

25

0.88(0.49–1.60)

0.685

Dominant

TT

69

123

1

 

122

70

1

 

TA + AA

74

221

0.60(0.40–0.89)

0.011

181

144

0.91(0.62–1.34)

0.640

Recessive

TT + TA

130

295

1

 

266

159

1

 

AA

13

49

0.60(0.32–1.16)

0.129

27

25

0.92(0.53–1.61)

0.782

Log-additive

0.67(0.49–0.91)

0.010

0.93(0.71–1.23)

0.633

rs56413992

Co-dominant

CC

90

129

1

 

180

108

1

 

CT

46

17

0.83(0.54–1.27)

0.386

108

67

1.02(0.69–1.52)

0.922

TT

7

90

0.86(0.34–2.17)

0.755

15

9

0.95(0.40–2.29)

0.911

Dominant

CC

90

198

1

 

180

108

1

 

CT + TT

53

146

0.83(0.55–1.25)

0.378

123

76

1.01(0.69–1.48)

0.953

Recessive

CC + CT

136

327

1

 

288

175

1

 

TT

7

14

0.92(0.37–2.29)

0.861

15

9

0.94(0.40–2.25)

0.897

Log-additive

0.87(0.62–1.22)

0.427

1.00(0.73–1.38)

0.999

  1. SNP single nucleotide polymorphism, DM diabetes mellitus, HTN hypertension, OR odds ratio, 95% CI 95% confidence interval
  2. p- values were calculated by logistic regression adjusted for age and gender
  3. Bold values indicated that the p-value was statistically significant