Fig. 3

Data processing and analysis. A The DEGs detected from the merged data are illustrated; the total 225 genes consisted of 130 downregulated and 95 upregulated genes. These genes were used to construct the IPPGEs. B The heatmap shows the DEG clustering in the patient and healthy samples. The Manhattan method was used for row and column clustering. C The significant pathways are illustrated. The numbers on the bars indicated the minus logarithm of q-value. D The induced signaling pathway which was extracted from the KEGG database using the DEGs