From: A brief comparison of polygenic risk scores and Mendelian randomisation
Applications | Polygenic risk score analysis | Mendelian Randomisation | Potential for bias due to horizontal pleiotropy? | Requires individual level data?a |
---|---|---|---|---|
Identifying an effect of an exposure on an outcome | ✓ | ✓ | ✓ | MR = NO PRS = YES |
Comparing outcomes in high versus low genetic risk for an exposure | ✓ | X | ✓ | YES |
Examining gene x environment interactions | ✓ | ✓ | ✓ | YESb |
Prediction modelling | ✓ | X | X | YES |
Quantifying shared genetic aetiology | ✓ | X | X | NO |
Identifying downstream effects of liability to a disease | ✓ | ✓ (“reverse MR” [3]) | ✓ | MR = NO PRS = YES |
Identifying biomarkers of disease | ✓ | ✓ | ✓ | MR = NO PRS = YES |