Fig. 3

Recurrence of REST binding loci with canonical and non-canonical RE1 motifs across ENCODE experiments. Among 68,975 REST ChIP-seq peaks from 23 different ENCODE REST ChIP-seq experiments, 4,072 peaks that have RE1 motifs were selected. The presented heatmap shows genome-wide RE1 motif profiles for these 4,072 selected RE1 motif sites. Each row corresponds to a specific experiment, whereas each column represents a distinct ChIP-seq peak. The axes are clustered and ordered based on the clustered outcomes. The ChIP-seq experiments are identified through a three-segmented nomenclature, comprising the ENCODE identifier, cell-line name, and tissue name. Color key of heatmap − 1) White: ‘NoPeak’ – no ChIPseq peak was found in the relevant genomic region, 2) Black: ‘Peak_cRE1’ – ChIPseq peak was found in the relevant genomic region with canonical RE1 motif, and 3) Other colors: ‘Peak_ncRE1’ – ChIPseq peak was found in the relevant genomic region with non-canonical RE1 motifs; Red (Altered_gap), Blue (Convergent), Green (Divergent), Purple (Flipped), Orange (L_only), and Yellow (R_only)