Table 2 Pathogenic mutation frequencies of 41 genes by subtype
Gene | GCB | non-GCB | P | FDR | ||
|---|---|---|---|---|---|---|
Number of cases of pathogenic mutation | Pathogenic mutation frequency (%, n = 36) | Number of cases of pathogenic mutation | Pathogenic mutation frequency (%, n = 60) | |||
KMT2D | 8 | 22 | 15 | 25 | 0.758 | 1.000 |
SOCS1 | 8 | 22 | 10 | 17 | 0.500 | 0.996 |
MYD88 | 6 | 17 | 12 | 20 | 0.685 | 0.996 |
MYD88 L265P | 4 | 11 | 8 | 13 | 1.000 | 1.000 |
CD79B | 2 | 6 | 14 | 23 | 0.024 | 0.320 |
PIM1 | 4 | 11 | 10 | 17 | 0.455 | 0.996 |
BTG1 | 4 | 11 | 10 | 17 | 0.455 | 0.996 |
SPEN | 3 | 8 | 8 | 13 | 0.679 | 0.996 |
TBL1XR1 | 3 | 8 | 8 | 13 | 0.679 | 0.996 |
SGK1 | 7 | 19 | 3 | 5 | 0.058 | 0.464 |
HIST1H1E | 7 | 19 | 3 | 5 | 0.058 | 0.464 |
CREBBP | 5 | 14 | 5 | 8 | 0.605 | 0.996 |
TET2 | 4 | 11 | 5 | 8 | 0.928 | 1.000 |
KLHL6 | 4 | 11 | 5 | 8 | 0.928 | 1.000 |
TNFRSF14 | 7 | 19 | 2 | 3 | 0.024 | 0.320 |
B2M | 5 | 14 | 4 | 7 | 0.416 | 0.996 |
FAS | 1 | 3 | 8 | 13 | 0.175 | 0.875 |
TP53 | 4 | 11 | 5 | 8 | 0.928 | 1.000 |
KMT2C | 2 | 6 | 6 | 10 | 0.703 | 0.996 |
CIITA | 0 | 0 | 8 | 13 | NA | NA |
CARD11 | 5 | 14 | 3 | 5 | 0.253 | 0.996 |
IRF4 | 1 | 3 | 7 | 12 | 0.253 | 0.996 |
NOTCH2 | 2 | 6 | 6 | 10 | 0.703 | 0.996 |
POU2F2 | 4 | 11 | 4 | 7 | 0.703 | 0.996 |
HIST1H1C | 6 | 17 | 1 | 2 | 0.020 | 0.320 |
MEF2B | 1 | 3 | 6 | 10 | 0.362 | 0.996 |
NOTCH1 | 3 | 8 | 4 | 7 | 1.000 | 1.000 |
GNA13 | 5 | 14 | 2 | 3 | 0.128 | 0.731 |
STAT3 | 5 | 14 | 2 | 3 | 0.128 | 0.731 |
STAT6 | 3 | 8 | 4 | 7 | 1.000 | 1.000 |
ETV6 | 0 | 0 | 6 | 10 | NA | NA |
CD70 | 1 | 3 | 5 | 8 | 0.514 | 0.996 |
BCL6 | 2 | 6 | 4 | 7 | 1.000 | 1.000 |
ACTB | 4 | 11 | 2 | 3 | 0.276 | 0.996 |
CD58 | 3 | 8 | 3 | 5 | 0.828 | 1.000 |
ARID1A | 3 | 8 | 2 | 3 | 0.553 | 0.996 |
FOXO1 | 3 | 8 | 2 | 3 | 0.553 | 0.996 |
PRDM1 | 3 | 8 | 2 | 3 | 0.553 | 0.996 |
PTEN | 3 | 8 | 2 | 3 | 0.553 | 0.996 |
BCL2 | 2 | 6 | 3 | 5 | 1.000 | 1.000 |
DDX3X | 2 | 6 | 3 | 5 | 1.000 | 1.000 |
EP300 | 1 | 3 | 4 | 7 | 0.722 | 0.996 |