Table 3 The Association between HLA-B*58:01 allele and SNPs with allopurinol-induced cADRs
HLA/SNPs allele | cADRs vs. tolerant control | SJS/TEN vs. tolerant control | DRESS vs. tolerant control | MPE vs. tolerant control | ||||
|---|---|---|---|---|---|---|---|---|
Odds ratio (95% CI) | P-value | Odds ratio (95% CI) | P-value | Odds ratio (95% CI) | P-value | Odds ratio (95% CI) | P-value | |
HLA-B*58:01 | 137.2 (38.3–670.5) | 1.7 × 10− 27 | 582.0 (62.2–5447.3) | 3.7 × 10− 23 | 92.2 (22.6–375.1) | 2.3 × 10− 14 | 63.7 (8.4–829.2) | 2.7 × 10− 6 |
BAT1 rs2734583, A > G | 43.5 (15.6–140.6) | 4.4 × 10− 20 | 90.1 (20.7–580.1) | 1.4 × 10− 15 | 47.6 (12.8–219.8) | 1.5 × 10− 12 | 7.8 (1.0–51.0) | 2.5 × 10− 2 |
BAT3 rs3117583, A > G | 10.4 (4.6–24.7) | 1.8 × 10− 10 | 20.5 (6.3–80.3) | 2.07 × 10− 9 | 7.3 (2.5–22.0) | 5.2 × 10− 5 | 5.2 (0.9–31.1) | 3.6 × 10− 2 |
CCHCR1 rs130077, G > A | 67.8 (22.9–234.9) | 1.1 × 10− 23 | 287.6 (37.6–12034.6) | 1.5 × 10− 18 | 47.6 (12.8–219.8) | 1.5 × 10− 12 | 20.9 ( 3.3–164.6) | 3.2 × 10− 4 |
CCHCR1 rs9263745, G > A | 77.7 (25.5–276.4) | 1.1 × 10− 24 | 287.6 (37.6–12034.6) | 1.5 × 10− 18 | 47.6 (12.8–219.8) | 1.5 × 10− 12 | 37.2 (5.4–436.9) | 2.1 × 10− 5 |
CCHCR1 rs9263785, T > G | 67.8 (22.9–234.9) | 1.1 × 10− 23 | 287.6 (37.6–12034.6) | 1.5 × 10− 18 | 47.6 (12.8–219.8) | 1.5 × 10− 12 | 20.9 ( 3.3–164.6) | 3.2 × 10− 4 |
HCP5 rs3099844, C > A | 41.8 (15.3–129.7) | 3.7 × 10− 20 | 40.1 (10.3–234.6) | 6.7 × 10− 12 | 27.5 (7.8–126.1) | 2.7 × 10− 10 | 5.6 (0.9–33.6) | 2.9 × 10− 2 |
HCP5 rs3131643, G > A | 23.3 (9.5–62.3) | 2.1 × 10− 16 | 78.7 (18.5–495.9) | 5.2 × 10− 15 | 54.2 (14.0–275.4) | 3.4 × 10− 13 | 6.8 (0.9–43.1) | 3.2 × 10− 2 |
HLA-C rs4084090, A > G | 47.9 (17.3–150.3) | 1.1 × 10− 21 | 181.9 (25.3–7691.2) | 2.4 × 10− 16 | 38.7 (10.6–185.4) | 8.2 × 10− 12 | 13.0 (2.2–95.7) | 1.6 × 10− 3 |
MSH5 rs1150793, A > G | 9.1 (4.1–20.9) | 1.2 × 10− 9 | 16.7 (5.3–64.5) | 1.7 × 10− 8 | 5.9 (2.1–17.5) | 2.2 × 10− 4 | 4.2 (0.7–24.9) | 5.9 × 10− 2 |
POLR2LP rs9263733, C > T | 96.1 (29.4–390.8) | 1.4 × 10− 25 | 395.2 (49.0–16306.3) | 7.1 × 10− 20 | 66.9 (16.6–345.1) | 1.1 × 10− 13 | 29.4 (4.3–247.9) | 1.06 × 10− 4 |
POU5F1 rs9263796, C > T | 67.8 (22.9–234.9) | 1.1 × 10− 23 | 287.6 (37.6–120 34.6) | 1.5 × 10− 18 | 47.6 (12.8–219.8) | 1.5 × 10− 12 | 20.9 ( 3.3–164.6) | 3.2 × 10− 4 |
PSORS1C1 rs2233945, C > A | 60.0 (20.6–203.6) | 9.7 × 10− 23 | 287.6 (37.4–12034.6) | 1.5 × 10− 18 | 37.9 (10.6–160.2) | 1.8 × 10− 11 | 20.9 ( 3.3–164.6) | 3.2 × 10− 4 |
PSORS1C1 rs9263726, G > A | 67.8 (22.9–234.9) | 1.1 × 10− 23 | 287.6 (37.6–12034.6) | 1.5 × 10− 18 | 47.6 (12.8–219.8) | 1.5 × 10− 12 | 20.9 ( 3.3–164.6) | 3.2 × 10− 4 |
TCF19 rs1044870, C > T | Inf (7.3 - Inf) | 2.0 × 10− 7 | Inf (0.8 - Inf) | 3.8 × 10− 2 | Inf (9.3 - Inf) | 6.2 × 10− 7 | Inf (11.4 - Inf2) | 1.3 × 10− 5 |
TCF19 rs9263794, A > G | 43.53 (15.9–134.2) | 5.3 × 10− 21 | 165.81 (23.3–7019.3) | 6.9 × 10− 16 | 35.2 (9.7–166.5) | 2.1 × 10− 11 | 11.87 (2.0–86.3) | 2.2 × 10− 3 |